Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Production of monoclonal antibodies: Strategy and tactics

1980 • 1,594 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

The glucose-regulated proteins: stress induction and clinical applications

2001 • 1,013 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

PERK mediates cell-cycle exit during the mammalian unfolded protein response

2000 • 447 citations

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

1972 • 431 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

The Unfolding Tale of the Unfolded Protein Response

2001 • 398 citations

Plasma cells: finding new light at the end of B cell development

2001 • 305 citations

The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

1999 • 231 citations

Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately.

1990 • 226 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

1996 • 189 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes.

1985 • 107 citations

Changes in J chain and mu chain RNA expression as a function of B cell differentiation.

1984 • 104 citations

Antigen-induced lymphomagenesis: identification of a murine B cell lymphoma with known antigen specificity.

1983 • 89 citations

A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells

1997 • 86 citations

Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin mu heavy chain cDNA.

1991 • 63 citations

Evidence for hydrophobic region within heavy chains of mouse B lymphocyte membrane-bound IgM

1979 • 49 citations

Interleukin-5 (IL-5) and IL-6 Define Two Molecularly Distinct Pathways of B-Cell Differentiation

1993 • 26 citations

The expression of membrane and secreted immunoglobulin during the in vitro differentiation of the murine B cell lymphoma CH12.

1987 • 18 citations