Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

2005 • 2,964 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

Analysis of Variance for Gene Expression Microarray Data

2000 • 1,339 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

2000 • 1,277 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

2004 • 942 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi

2001 • 697 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

2003 • 635 citations

XBP1

2004 • 627 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.

1997 • 408 citations

S‐Adenosylmethionine: a control switch that regulates liver function

2002 • 406 citations

Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages

1995 • 397 citations

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 ^IPK

2002 • 360 citations

INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

2004 • 347 citations

WormBase: network access to the genome and biology of Caenorhabditis elegans

2001 • 336 citations

Block of HAC1 mRNA Translation by Long-Range Base Pairing Is Released by Cytoplasmic Splicing upon Induction of the Unfolded Protein Response

2001 • 328 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response

2001 • 291 citations

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

2005 • 286 citations

Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

1997 • 283 citations

The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum

2004 • 282 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Phosphatidylcholine and cell death

2002 • 220 citations

A survival pathway forCaenorhabditis eleganswith a blocked unfolded protein response

2002 • 200 citations

Using ANOVA to Analyze Microarray Data

2004 • 160 citations

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

2001 • 158 citations

The Mammalian Calcium-binding Protein, Nucleobindin (CALNUC), Is a Golgi Resident Protein

1998 • 154 citations

Transglycosidase Activity of Chitotriosidase

2003 • 151 citations

Palindrome with Spacer of One Nucleotide Is Characteristic of the cis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae

1998 • 146 citations

Opposing Roles for ATF6α and ATF6β in Endoplasmic Reticulum Stress Response Gene Induction

2004 • 136 citations

Luman, the Cellular Counterpart of Herpes Simplex Virus VP16, Is Processed by Regulated Intramembrane Proteolysis

2002 • 134 citations

Overexpression of CALNUC (Nucleobindin) Increases Agonist and Thapsigargin Releasable Ca2+ Storage in the Golgi

1999 • 131 citations

Fine-tuning of the Escherichia coli σ^E envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA

2004 • 115 citations

Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress

2004 • 114 citations

Apoptosis of Insulin-Secreting Cells Induced by Endoplasmic Reticulum Stress Is Amplified by Overexpression of Group VIA Calcium-Independent Phospholipase A₂ (iPLA₂β) and Suppressed by Inhibition of iPLA₂β

2004 • 106 citations

Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF

1997 • 103 citations

The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma

2005 • 99 citations

L-Methionine Availability Regulates Expression of the Methionine Adenosyltransferase 2A Gene in Human Hepatocarcinoma Cells

2003 • 79 citations

A Novel Member of the Tob Family of Proteins Controls Sexual Fate in Caenorhabditis elegans Germ Cells

2000 • 77 citations

Distinct and Redundant Functions of μ1 Medium Chains of the AP-1 Clathrin-Associated Protein Complex in the NematodeCaenorhabditis elegans

2000 • 63 citations

From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design

2003 • 37 citations

ire-1-dependent Transcriptional Up-regulation of a Lumenal Uridine Diphosphatase from Caenorhabditis elegans

2004 • 17 citations