Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Protein folding in the cell

1992 • 4,138 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

1996 • 1,017 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells

1987 • 442 citations

tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response

1996 • 440 citations

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

1989 • 421 citations

Stress signaling in yeast

1995 • 415 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

Signal transduction in yeast

1994 • 385 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway

1996 • 363 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

Stress-induced transcriptional activation

1995 • 325 citations

[14] Cloning genes by complementation in yeast

1991 • 266 citations

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.

1993 • 246 citations

The tunicamycins — useful tools for studies on glycoproteins

1981 • 227 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

The Unfolded Protein Response Pathway in

1996 • 180 citations

A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.

1996 • 176 citations

The unfolded-protein-response pathway in yeast

1994 • 154 citations

A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

1995 • 151 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

Transcription factors 2: helix-loop-helix.

1995 • 149 citations

Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast.

1991 • 137 citations

Stress-induced transcriptional activation.

1995 • 133 citations

The subnuclear localization of tRNA ligase in yeast.

1987 • 133 citations

Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression

1996 • 119 citations

Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae

1995 • 107 citations

[45] Analysis of polypeptide transit through yeast secretory pathway

1991 • 96 citations

The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum.

1993 • 90 citations

The cellular response to unfolded proteins: intercompartmental signaling

1994 • 81 citations

SSI1 Encodes a Novel Hsp70 of the Saccharomyces cerevisiae Endoplasmic Reticulum

1996 • 78 citations

Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.

1987 • 73 citations

Hac1: A novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdcW mutant of Schizosaccharomyces pombe

1994 • 72 citations

Endoplasmicreticulum-induced signal transduction and gene expression

1997 • 64 citations

Molecular Structure of a Yeast Gene, PDI1, Encoding Protein Disulfide Isomerase That Is Essential for Cell Growth

1991 • 54 citations

Cer1p, a Novel Hsp70-related Protein Required for Posttranslational Endoplasmic Reticulum Translocation in Yeast

1996 • 54 citations

The Yeast EUG1 Gene Encodes an Endoplasmic Reticulum Protein That Is Functionally Related to Protein Disulfide Isomerase

1992 • 35 citations

RNA splicing: Unexpected spliceosome diversity

1996 • 33 citations

Protein Folding in the Endoplasmic Reticulum

1993 • 10 citations