Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation

A new mathematical model for relative quantification in real-time RT-PCR

2001 • 32,396 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

Translational control in the endoplasmic reticulum stress response

2002 • 783 citations

Proteases for Cell Suicide: Functions and Regulation of Caspases

2000 • 720 citations

Translational control in the endoplasmic reticulum stress response

2002 • 686 citations

Cellular and Chemical Events During Enamel Maturation

1998 • 681 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

Molecular Mechanisms of Dental Enamel Formation

1995 • 455 citations

D<scp>ental</scp> F<scp>luorosis</scp>: C<scp>hemistry and</scp> B<scp>iology</scp>

2002 • 406 citations

The Metabolism and Toxicity of Fluoride

1990 • 361 citations

Identification of novel stress-induced genes downstream of chop

1998 • 306 citations

Unfolded Protein Response

2011 • 210 citations

The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression

2000 • 204 citations

Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45

1998 • 179 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements

1999 • 166 citations

Refining the Estimate of the Critical Period for Susceptibility to Enamel Fluorosis in Human Maxillary Central Incisors

1995 • 165 citations

An Epidemiologic Estimate of the Critical Period during which Human Maxillary Central Incisors Are Most Susceptible to Fluorosis

1991 • 151 citations

CHOP-Dependent Stress-Inducible Expression of a Novel Form of Carbonic Anhydrase VI

1999 • 146 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Quantitative analysis of cell turnover in the enamel organ of the rat incisor. Evidence for ameloblast death immediately after enamel matrix secretion

1977 • 128 citations

Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ

1992 • 122 citations

Dental Fluorosis: Variability among Different Inbred Mouse Strains

2002 • 119 citations

Skeletal fluorosis: Histomorphometric analysis of bone changes and bone fluoride content in 29 patients

1989 • 119 citations

Fluoride-Induced Apoptosis in Epithelial Lung Cells Involves Activation of MAP Kinases p38 and Possibly JNK

2001 • 103 citations

Fluoride intake from foods, beverages and dentifrice by young children in communities with negligibly and optimally fluoridated water: a pilot study

1999 • 93 citations

Cell death induced by topoisomerase inhibitors

1991 • 89 citations

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

1999 • 87 citations

Fluoride-induced apoptosis in human epithelial lung cells (A549 cells): role of different G protein-linked signal systems

2003 • 85 citations

Effects of chronic fluoride exposure on morphometric parameters defining the stages of amelogenesis and ameloblast modulation in rat incisors

1993 • 80 citations

Mineral Acquisition Rates in Developing Enamel on Maxillary and Mandibular Incisors of Rats and Mice: Implications to Extracellular Acid Loading as Apatite Crystals Mature

2005 • 80 citations

Altered pH Regulation During Enamel Development in the Cystic Fibrosis Mouse Incisor

2003 • 77 citations

Is Fluoride Concentration in Dentin and Enamel a Good Indicator of Dental Fluorosis?

2004 • 72 citations

Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells

2000 • 70 citations

Autocrine Human Growth Hormone (hGH) Regulation of Human Mammary Carcinoma Cell Gene Expression

2001 • 59 citations

Fluoride Inhibition of Protein and DNA Synthesis in Cells in Vitro

1979 • 57 citations

DNA localization in nuclear fragments of apoptotic ameloblasts using anti-DNA immunoelectron microscopy: Programmed cell death of ameloblasts

1995 • 53 citations

Nuclear DNA fragmentation during postnatal tooth development of mouse and hamster and during dentin repair in the rat

1996 • 52 citations

Developmental analysis and computer modelling of bioengineered teeth

2005 • 49 citations

Inorganic fluoride. Divergent effects on human proximal tubular cell viability.

1997 • 48 citations

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

1999 • 39 citations

Apoptotic cell death following exposure to fluoride in rat alveolar macrophages

1996 • 37 citations

In situ detection of apoptosis in dental and periodontal tissues of the adult mouse using annexin-V-biotin

2000 • 35 citations

Expression of stress response genes GADD153, c-jun, and Heme Oxygenase-1 in H2O2 and O2-resistant fibroblasts

1996 • 35 citations

Fluoride mediates apoptosis in osteosarcoma UMR 106 and its cytotoxicity depends on the pH

1997 • 34 citations

The immunohistochemical localization of Bax and Bcl-2 and their relation to apoptosis during amelogenesis in developing rat molars

2001 • 34 citations

Influence of fluoride on secretory pathway of the secretory ameloblast in rat incisor tooth germs exposed to sodium fluoride

1996 • 32 citations

Morphometry and autoradiography of altered rat enamel protein processing due to chronic exposure to fluoride

1996 • 29 citations

Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells

2002 • 29 citations

Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells

2002 • 27 citations

Micro-electrode Techniques for the Analysis of Oral Fluids

1987 • 21 citations

Down-regulation of gadd153 by c-myc in rat fibroblasts and its effect on cell growth and radiation-induced apoptosis.

1996 • 18 citations

Involvement of Protein Kinase C in Fluoride‐Induced Apoptosis in Different Types of Lung Cells

2002 • 15 citations

Gadd153 restores resistance to radiation-induced apoptosis after thiol depletion

2003 • 9 citations