Redox metals and neu rodegenerative disease

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1998 • 1,207 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Copper Stimulates Endocytosis of the Prion Protein

1998 • 586 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes

1997 • 318 citations

Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1998 • 287 citations

Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury

1998 • 254 citations

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1998 • 249 citations

Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine

1998 • 227 citations

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

1996 • 227 citations

Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

1998 • 219 citations

Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection

1997 • 202 citations

Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral Sclerosis

1998 • 171 citations

Abnormal localization of iron regulatory protein in Alzheimer's disease

1998 • 170 citations

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

1998 • 161 citations

Effects of Copper on Survival of Prion Protein Knockout Neurons and Glia

1998 • 159 citations

In Vitro Studies of Ferritin Iron Release and Neurotoxicity

1998 • 152 citations

Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases

1998 • 142 citations

Astrocytes, brain aging, and neurodegeneration

1996 • 139 citations

Promotion of transition metal-induced reactive oxygen species formation by β-amyloid

1998 • 139 citations

Copper-Binding Amyloid Precursor Protein Undergoes a Site-Specific Fragmentation in the Reduction of Hydrogen Peroxide

1998 • 127 citations

Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine: A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease

1997 • 127 citations

Activation of iron regulatory protein-1 by oxidative stress in vitro

1998 • 126 citations

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H ₂ O ₂

1998 • 118 citations

Subunit asymmetry in the three‐dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

1998 • 113 citations

Manganese: A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of Parkinsonism

1998 • 106 citations

Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease

1998 • 103 citations

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

1998 • 93 citations

Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

1999 • 79 citations

Abnormal Iron Deposition Associated With Lipid Peroxidation in Transgenic Mice Expressing Interleukin-6 in the Brain

1998 • 72 citations

Essential trace element alterations in amyotrophic lateral sclerosis

1997 • 63 citations

Reactions of Hydrogen Peroxide with Familial Amyotrophic Lateral Sclerosis Mutant Human Copper-Zinc Superoxide Dismutases Studied by Pulse Radiolysis

1998 • 62 citations

Astrocyte Mitochondria: A Substrate for Iron Deposition in the Aging Rat Substantia Nigra

1998 • 58 citations

The Familial Amyotrophic Lateral Sclerosis-Associated Amino Acid Substitutions E100G, G93A, and G93R Do Not Influence the Rate of Inactivation of Copper- and Zinc-Containing Superoxide Dismutase by H2O2

1998 • 40 citations

Activated microglia cause iron-dependent lipid peroxidation in the presence of ferritin

1998 • 39 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

1995 • 34 citations

Thiol-dependent metal-catalyzed oxidation of copper, zinc superoxide dismutase

1998 • 27 citations