Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

GLUTATHIONE

1983 • 5,487 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Glutathione and its role in cellular functions

1999 • 1,693 citations

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

Regulation of matrix metalloproteinase expression in tumor invasion

1999 • 1,503 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Biologic and pharmacologic regulation of mammalian glutathione synthesis

1999 • 1,178 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Recent Trends in Glutathione Biochemistry—Glutathione–Protein Interactions: A Molecular Link between Oxidative Stress and Cell Proliferation?

1998 • 482 citations

Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches

2000 • 478 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

1997 • 470 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Expression of matrix metalloproteinase-2 and -9 during early human wound healing.

1994 • 411 citations

Protein Sulfhydryls and Their Role in the Antioxidant Function of Protein S-Thiolation

1995 • 409 citations

Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite

2000 • 387 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Nitric oxide and virus infection

2000 • 365 citations

Reaction of Uric Acid with Peroxynitrite and Implications for the Mechanism of Neuroprotection by Uric Acid

2000 • 346 citations

Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes

1991 • 307 citations

The role of glutathione in the transport and catabolism of nitric oxide

1996 • 271 citations

Peroxynitrite Modification of Protein Thiols: Oxidation, Nitrosylation, and S-Glutathiolation of Functionally Important Cysteine Residue(s) in the Sarcoplasmic Reticulum Ca-ATPase

1999 • 253 citations

Deficiency of Alveolar Fluid Glutathione in Patients with Sepsis and the Adult Respiratory Distress Syndrome

1991 • 252 citations

Hydroxyl Radical Formation during Peroxynitrous Acid Decomposition

1999 • 249 citations

Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

1997 • 226 citations

Characterization of Sulfur-centered Radical Intermediates Formed during the Oxidation of Thiols and Sulfite by Peroxynitrite

1996 • 222 citations

Characteristic Elevation of Matrix Metalloproteinase Activity in Idiopathic Interstitial Pneumonias

2000 • 217 citations

Tyrosine Nitration by Peroxynitrite Formed from Nitric Oxide and Superoxide Generated by Xanthine Oxidase

2000 • 186 citations

Tyrosine Nitration by Simultaneous Generation of ⋅NO and O⨪2 under Physiological Conditions

2000 • 176 citations

Effects of Tetracyclines on Neutrophil, Gingival, and Salivary Collagenases

1994 • 172 citations

Activation of Human Matrix Metalloproteinases by Various Bacterial Proteinases

1997 • 170 citations

Inactivation of tissue inhibitor of metalloproteinase‐1 by peroxynitrite

1996 • 170 citations

Formation of S-Nitrosothiols via Direct Nucleophilic Nitrosation of Thiols by Peroxynitrite with Elimination of Hydrogen Peroxide

1998 • 154 citations

Enhanced Vascular Permeability in Solid Tumor Involving Peroxynitrite and Matrix Metalloproteinases

2001 • 147 citations

S-Nitroglutathione, a Product of the Reaction between Peroxynitrite and Glutathione That Generates Nitric Oxide

1998 • 134 citations

Nitrosation of Uric Acid by Peroxynitrite

1998 • 129 citations

Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue

2000 • 118 citations

Regulation of HIV-1 Protease Activity through Cysteine Modification

1996 • 101 citations

Glutathiolation of Proteins by Glutathione DisulfideS-Oxide Derived from S-Nitrosoglutathione

2001 • 76 citations

A New Principle of Regulation of Enzymic Activity

1981 • 67 citations

Photodynamically Generated Bovine Serum Albumin Radicals: Evidence for Damage Transfer and Oxidation at Cysteine and Tryptophan Residues

1998 • 61 citations

Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue

2000 • 60 citations

Novel Functions of Human α1-Protease Inhibitor after S-Nitrosylation: Inhibition of Cysteine Protease and Antibacterial Activity

2000 • 48 citations

Organic nitrates, thionitrates, peroxynitrites, and nitric oxide: a molecular orbital study of the (X = O, S) rearrangement, a reaction of potential biological significance

1995 • 45 citations

Mechanisms of biologicalS-nitrosation and its measurement

2000 • 42 citations

Collagenase in Rheumatoid Arthritis

1985 • 8 citations