Enzymology of mitomycin C metabolic activation in tumour tissue

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

DT-diaphorase as a quinone reductase: A cellular control device against semiquinone and superoxide radical formation

1982 • 530 citations

[56] DT diaphorase

1967 • 521 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Mitomycin C: a review

1976 • 441 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

1990 • 261 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

DT-diaphorase in activation and detoxification of quinones

1993 • 188 citations

Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.

1986 • 144 citations

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

1981 • 132 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1993 • 116 citations

EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1993 • 106 citations

Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA

1992 • 105 citations

Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.

1994 • 99 citations

Characterization of Benzo[a]pyrene Quinone-Induced Toxicity to Primary Cultured Bone Marrow Stromal Cells from DBA/2 Mice: Potential Role of Mitochondrial Dysfunction

1995 • 86 citations

Enzymatic conversion of vitamin B12a to adenosyl-B12: Evidence for the existence of two separate reducing systems

1969 • 84 citations

Reductive activation of mitomycin C

1988 • 78 citations

Microsomal Marker Enzymes and their Limitations in Distinguishing the Outer Membrane of Rat Liver Mitochondria from the Microsomes

1969 • 76 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

Isolation and characterization of a major adduct between mitomycin C and DNA

1988 • 66 citations

The diffusion of a tumour-specific monoclonal antibody in lymphoma infiltrated spleen

1987 • 60 citations

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

1992 • 54 citations

Autocatalytic quinone methide formation from mitomycin c

1986 • 53 citations

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

1992 • 50 citations

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H:(quinone-acceptor)oxidoreductase

1988 • 49 citations

Re-evaluation of the molecular pharmacology of mitomycin C

1995 • 49 citations

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

1991 • 43 citations

Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.

1993 • 39 citations

The enzymology of doxorubicin quinone reduction in tumour tissue

1992 • 38 citations

Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?

1987 • 30 citations

Characterization of L5178Y murine lymphoblasts resistant to quinone antitumor agents.

1988 • 30 citations

EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

1995 • 29 citations

Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions.

1993 • 26 citations

NADH- and NADPH-linked aquacobalamin reductases occur in both mitochondrial and microsomal membranes of rat liver

1989 • 22 citations

Determination of mitomycin C, 2,7-diaminomitosene, 1,2-cis- and 1,2-trans-1-hydroxy-2,7-diaminomitosene in tumour tissue by high-performance liquid chromatography

1993 • 21 citations

Some Biologic Characteristics of Transplantable Lines of Mouse Adenocarcinomas of the Colon<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 20 citations

Reduction of Oxygen by NADH/NADH Dehydrogenase in the Presence of adriamycin

1986 • 18 citations

Occurrence and Tissue Distribution of Both NADH- and NADPH-linked Aquacobalamin Reductases in Some Vertebrates

1990 • 15 citations

NADPH-cytochrome c (P-450) reductase has the activity of NADPH-linked aquacobalamin reductase in rat liver microsomes

1992 • 12 citations

Cytochrome b5/Cytochrome b5 Reductase Complex in Rat Liver Microsomes has NADH-Linked Aquacobalamin Reductase Activity

1992 • 10 citations

Mitochondrial NADPH-Linked Aquacobalamin Reductase Is Distinct from the NADPH-Linked Enzyme from Microsomal Membranes in Rat Liver

1993 • 9 citations

Effect of a subcutaneously growing Walker 256 carcinosarcoma on host tissue mitochondrial function and magnesium content.

1984 • 5 citations