A novel iron chelator that does not induce HIF-1 activity

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Free radicals in biology and medicine

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

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C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

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Free radicals in biology and medicine

1985 • 2,999 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Iron and infection

1978 • 1,108 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

2001 • 1,009 citations

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

2001 • 930 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Haem oxygenase-1 prevents cell death by regulating cellular iron

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Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1

1997 • 400 citations

Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?

1989 • 385 citations

Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21^waf1/cip1, and Erythropoietin

1999 • 319 citations

Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency

2000 • 275 citations

The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site

1995 • 228 citations

Central Role of Ferrous/Ferric Iron in the Ultraviolet B Irradiation-mediated Signaling Pathway Leading to Increased Interstitial Collagenase (Matrix-degrading Metalloprotease (MMP)-1) and Stromelysin-1 (MMP-3) mRNA Levels in Cultured Human Dermal Fibroblasts

1998 • 228 citations

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

2000 • 210 citations

HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation

1999 • 184 citations

Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin

1999 • 177 citations

Oxygen sensing and signaling: impact on the regulation of physiologically important genes

1999 • 170 citations

Iron-Chelating Therapy

1988 • 149 citations

Hypoxia and the regulation of gene expression

1998 • 127 citations

Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line

1995 • 119 citations

Iron Regulatory Proteins 1 and 2 Bind Distinct Sets of RNA Target Sequences

1996 • 115 citations

Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells

1987 • 101 citations

Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation

2000 • 80 citations

Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation

2000 • 76 citations

Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans

2000 • 65 citations

Reduction of ultraviolet light-induced oxidative stress by amino acid-based iron chelators

1999 • 35 citations

Hypoxia Increases Glyceraldehyde-3-phosphate Dehydrogenase Transcription in Rat Alveolar Epithelial Cells

1999 • 31 citations

Regulation of Erythropoietin Gene Expression Depends on Two Different Oxygen-Sensing Mechanisms

1999 • 17 citations

Modulation of transduced erythropoietin expression by iron

2000 • 15 citations