The Hedgehog Response Network: Sensors, Switches, and Routers

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

2003 • 1,465 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

A Second Canon

2003 • 1,329 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

2003 • 1,243 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

2003 • 1,066 citations

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

2004 • 990 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

2002 • 788 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

2003 • 695 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance

2003 • 628 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

2001 • 542 citations

A Mechanism for Wnt Coreceptor Activation

2004 • 541 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

2000 • 394 citations

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

2002 • 381 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

2003 • 339 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Novel Lipid Modifications of Secreted Protein Signals

2004 • 319 citations

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

2002 • 294 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo

2003 • 265 citations

Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression

1999 • 262 citations

Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2

2003 • 243 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

2002 • 215 citations

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

2003 • 200 citations

Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

2000 • 197 citations

Altered localization ofDrosophilaSmoothened protein activates Hedgehog signal transduction

2003 • 186 citations

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

2002 • 185 citations

Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus

2000 • 180 citations

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

2002 • 179 citations

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

1999 • 178 citations

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

1998 • 169 citations

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

2003 • 169 citations

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

2001 • 152 citations

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis ofDrosophila

2003 • 142 citations

Similarities between the Hedgehog and Wnt signaling pathways

2002 • 141 citations

Gli regulation by the opposing activities of Fused and Suppressor of Fused

2000 • 137 citations

The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels

1999 • 135 citations

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.

1992 • 130 citations

Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators

1999 • 127 citations

Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation

2000 • 118 citations

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

2003 • 117 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues

2004 • 107 citations

Phosphorylation of the fused protein kinase in response to signaling from hedgehog.

1996 • 105 citations

Smoothened translates Hedgehog levels into distinct responses

2003 • 77 citations

slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development

1998 • 64 citations

Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

2004 • 64 citations

Genetic Dissection of the Drosophila Cubitus interruptus Signaling Complex

2001 • 57 citations

Cubitus interruptus Requires DrosophilaCREB-Binding Protein To Activate wingless Expression in the Drosophila Embryo

2000 • 31 citations