Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Induction of Drosophila eye development by Decapentaplegic

1997 • 567 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

The world according to bedgebog

1997 • 549 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-β family in Drosophila

1991 • 330 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

1998 • 303 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Repression of ci-D in posterior compartments of Drosophila by engrailed.

1990 • 205 citations

Problems and paradigms: Morphogens and pattern formation

1997 • 184 citations

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

1998 • 169 citations

Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway

1998 • 155 citations

Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes

1997 • 140 citations

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.

1995 • 134 citations

engrailedexpression in the anterior lineage compartment of the developing wing blade ofDrosophila

1992 • 134 citations

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

1995 • 103 citations

Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs

1998 • 102 citations

Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.

1993 • 85 citations

Review

1997 • 81 citations

The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs

1996 • 61 citations

Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer

1997 • 54 citations

Cross-screening: a new method to assemble clones rapidly and unambiguously into contigs.

1996 • 12 citations

Use of ordered deletions in genome sequencing

1997 • 8 citations

Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway

1998 • 5 citations