Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

1999 • 1,756 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes

1997 • 1,421 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage

2002 • 1,351 citations

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

1993 • 1,319 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

1993 • 1,166 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

1 Developmental roles and clinical significance of Hedgehog signaling

2003 • 896 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

2000 • 839 citations

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

1993 • 807 citations

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

2002 • 788 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

Multipotent progenitor cells in the adult dentate gyrus

1998 • 722 citations

Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

1993 • 714 citations

In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain

2001 • 702 citations

Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

2002 • 671 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

2001 • 642 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2

2001 • 586 citations

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

1994 • 583 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

2001 • 555 citations

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

1995 • 542 citations

Targeting of cre to the Foxg1 (BF-1) Locus Mediates loxP Recombination in the Telencephalon and Other Developing Head Structures

2000 • 535 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia

1999 • 490 citations

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

2002 • 484 citations

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

2001 • 477 citations

Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon

2001 • 443 citations

Multiple and novel specificities of monoclonal antibodies O1, O4, and R‐mAb used in the analysis of oligodendrocyte development

1989 • 422 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2

2000 • 391 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon

2001 • 325 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain

2001 • 284 citations

Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling

2002 • 272 citations

hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila

1996 • 269 citations

TheGsh2homeodomain gene controls multiple aspects of telencephalic development

2000 • 228 citations

Selective expression of PDGF A and its receptor during early mouse embryogenesis

1990 • 215 citations

The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

1993 • 209 citations

Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

1998 • 177 citations

A method for rapid gain-of-function studies in the mouse embryonic nervoussystem

1999 • 174 citations

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo

2002 • 172 citations

Apoptosis and brain development

2001 • 163 citations

The role of segment polarity genes during early oogenesis in Drosophila

1996 • 156 citations

Yb Modulates the Divisions of Both Germline and Somatic Stem Cells through piwi- and hh-Mediated Mechanisms in the Drosophila Ovary

2001 • 152 citations

Immunocytochemical localization by electron microscopy of 2'3'-cyclic nucleotide 3'-phosphodiesterase in developing oligodendrocytes of normal and mutant brain

1988 • 148 citations

Altered Forebrain and Hindbrain Development in Mice Mutant for theGsh-2Homeobox Gene

1997 • 105 citations

Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling

2000 • 103 citations

Mosaic Analysis in the Drosophila Ovary Reveals a Common Hedgehog-Inducible Precursor Stage for Stalk and Polar Cells

1999 • 103 citations

The patched gene in development and cancer

1998 • 102 citations

Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo

2000 • 96 citations

Sonic Hedgehog Is Required during an Early Phase of Oligodendrocyte Development in Mammalian Brain

2001 • 85 citations

Lineage, migration, and fate determination of postnatal subventricular zone cells in the mammalian CNS

1995 • 75 citations

The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human

1998 • 43 citations