Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

The primary structure of transcription factor TFIIIA has 12 consecutive repeats

1985 • 413 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

1997 • 275 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins

1992 • 233 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Catching a Gli-mpse of Hedgehog

1997 • 198 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

CREB-binding Protein Activates Transcription through Multiple Domains

1996 • 170 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning

1995 • 160 citations

Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes

1997 • 140 citations

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

1997 • 115 citations

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

1995 • 103 citations

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog inDrosophila embryos

1997 • 80 citations

GLI3 Encodes a 190-Kilodalton Protein with Multiple Regions of GLI Similarity

1990 • 35 citations

Induction of a mirror-image duplication of anterior wing structures by localized hedgehog expression in the anterior compartment of Drosophila melanogaster wing imaginal discs

1994 • 28 citations