Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons

1988 • 739 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

1999 • 703 citations

Sonic hedgehog is essential to foregut development

1998 • 685 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM

1999 • 536 citations

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

1999 • 528 citations

Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development

1997 • 527 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Gli proteins encode context-dependent positive and negative functions: implications for development and disease

1999 • 392 citations

Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor Neurons

1998 • 383 citations

A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord

1999 • 363 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 356 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 326 citations

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.

1997 • 323 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Complementary Domains of Retinoic Acid Production and Degradation in the Early Chick Embryo

1999 • 279 citations

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

1997 • 275 citations

Sonic hedgehog controls epaxial muscle determination through Myf5 activation

1999 • 269 citations

Hedgehog and Patched in Neural Development and Disease

1998 • 259 citations

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog

1998 • 243 citations

Gli3 is required for Emx gene expression during dorsal telencephalon development

1999 • 231 citations

PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development

1997 • 212 citations

Differential Distribution of Retinoic Acid Synthesis in the Chicken Embryo as Determined by Immunolocalization of the Retinoic Acid Synthetic Enzyme, RALDH-2

1999 • 184 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

GLI 3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization

1999 • 173 citations

Ci: a complex transducer of the Hedgehog signal

1999 • 171 citations

Convergent Inductive Signals Specify Midbrain, Hindbrain, and Spinal Cord Identity in Gastrula Stage Chick Embryos

1999 • 156 citations

Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

1997 • 149 citations

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord

1998 • 141 citations

Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.

1997 • 123 citations

Expression Patterns of Developmental Control Genes in Normal andEngrailed-1Mutant Mouse Spinal Cord Reveal Early Diversity in Developing Interneurons

1997 • 109 citations

Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons

1998 • 104 citations

Early regional variations in motoneuron numbers arise by differential proliferation in the chick embryo spinal cord

1989 • 87 citations

Recent advances in hedgehog signalling

1997 • 84 citations

The Xt J allele generates a Gli 3 fusion transcript

1998 • 59 citations

Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice

1996 • 55 citations