The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

2002 • 1,442 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

1998 • 1,272 citations

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 • 1,253 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling

2000 • 686 citations

Chemotropic guidance of developing axons in the mammalian central nervous system

1988 • 681 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

2001 • 642 citations

cAMP-induced switching in turning direction of nerve growth cones

1997 • 614 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

RETRACTED: Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex

2001 • 603 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Turning of nerve growth cones induced by neurotransmitters

1994 • 583 citations

THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM

1999 • 536 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

2002 • 484 citations

Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons

1996 • 459 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

1996 • 403 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Guidance Cues at the Drosophila CNS Midline: Identification and Characterization of Two Drosophila Netrin/UNC-6 Homologs

1996 • 322 citations

Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC

1997 • 280 citations

Frizzled-3Is Required for the Development of Major Fiber Tracts in the Rostral CNS

2002 • 268 citations

Sonic hedgehog in CNS development: one signal, multiple outputs

2002 • 259 citations

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

2002 • 257 citations

BMPs as Mediators of Roof Plate Repulsion of Commissural Neurons

1999 • 249 citations

C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor

2001 • 233 citations

Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

1998 • 229 citations

Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant

1990 • 227 citations

The Role of the Floor Plate in Axon Guidance

1995 • 218 citations

Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog

2001 • 174 citations

Identification of Maxillary Factor, a Maxillary Process–Derived Chemoattractant for Developing Trigeminal Sensory Axons

1999 • 103 citations

Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway

2001 • 89 citations

Hedgehog Signaling in Germ Cell Migration

2001 • 85 citations

Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord

1999 • 67 citations