Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

2007 • 2,820 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

2007 • 2,762 citations

A new multipoint method for genome-wide association studies by imputation of genotypes

2007 • 2,593 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

2007 • 2,187 citations

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

2008 • 1,838 citations

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

2007 • 1,750 citations

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

2007 • 1,683 citations

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

2007 • 1,681 citations

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

2003 • 1,435 citations

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

2007 • 1,426 citations

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

2007 • 1,358 citations

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

2008 • 1,273 citations

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

2007 • 1,145 citations

Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes

2003 • 1,002 citations

Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

2004 • 777 citations

Newly identified genetic risk variants for celiac disease related to the immune response

2008 • 669 citations

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

2007 • 662 citations

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

2007 • 628 citations

The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly

2001 • 549 citations

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

2007 • 549 citations

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

2008 • 469 citations

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

2008 • 467 citations

Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes

2003 • 416 citations

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

2007 • 413 citations

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

2006 • 394 citations

An immune origin of type 2 diabetes?

2005 • 391 citations

Rheumatoid arthritis association at 6q23

2007 • 385 citations

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

2005 • 332 citations

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

2008 • 304 citations

Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

2003 • 289 citations

Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

2008 • 222 citations

Genetic Analysis of the Interleukin-18 System Highlights the Role of the Interleukin-18 Gene in Cardiovascular Disease

2005 • 222 citations

IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions

2003 • 220 citations

Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes

2005 • 212 citations

Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis

2002 • 210 citations

Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls

2007 • 207 citations

Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels

2007 • 166 citations

Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced

2004 • 137 citations

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects

2007 • 117 citations

A new class of obesity genes encodes leukocyte adhesion receptors

1997 • 103 citations

Association of Systemic Concentrations of Macrophage Migration Inhibitory Factor With Impaired Glucose Tolerance and Type 2 Diabetes

2006 • 96 citations

Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case–Cohort Study, 1984–2002

2007 • 93 citations

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

2006 • 90 citations

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

2007 • 89 citations

Comprehensive Survey of Common Genetic Variation at the Plasminogen Activator Inhibitor-1 Locus and Relations to Circulating Plasminogen Activator Inhibitor-1 Levels

2005 • 67 citations

An Interleukin-18 Polymorphism Is Associated With Reduced Serum Concentrations and Better Physical Functioning in Older People

2007 • 67 citations

The Accelerator Hypothesis: A Unifying Explanation for Type-1 and Type-2 Diabetes

2006 • 21 citations