Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

1987 • 308 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

1990 • 190 citations

MHC-Linked Protection from Diabetes Dissociated from Clonal Deletion of T Cells

1990 • 167 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.

1991 • 130 citations

Understanding autoimmune diabetes: insights from mouse models

2002 • 118 citations

Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.

1996 • 101 citations

Diabetes in non‐obese diabetic mice is not associated with quantitative changes in CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells

2007 • 95 citations

Autoantigen-Independent Deletion of Diabetogenic CD4+ Thymocytes by Protective MHC Class II Molecules

1999 • 54 citations

The effect of bone marrow and thymus chimerism between non‐obese diabetic (NOD) and NOD‐E transgenic mice, on the expression and prevention of diabetes

1993 • 40 citations

Inhibition of Autoimmune Diabetes in Nonobese Diabetic Mice by Transgenic Restoration of H2-E MHC Class II Expression: Additive, But Unequal, Involvement of Multiple APC Subtypes

2001 • 34 citations

Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules

1992 • 23 citations

Linkage betweenTcrb-V and a gene responsible for deletion of Tcrb-V11 + T cells

1990 • 22 citations

IL-12 Administration Reveals Diabetogenic T Cells in Genetically Resistant I-Eα-Transgenic Nonobese Diabetic Mice: Resistance to Autoimmune Diabetes Is Associated with Binding of Eα-Derived Peptides to the I-Ag7 Molecule

2001 • 14 citations

A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes.

1999 • 12 citations

A Peptide Binding Motif for I-Eg7, the MHC Class II Molecule That Protects Eα-Transgenic Nonobese Diabetic Mice from Autoimmune Diabetes

1999 • 9 citations

Disease‐protected major histocompatibility complex Ea‐transgenic non‐obese diabetic (NOD) mice show interleukin‐4 production not seen in susceptible Ea‐transgenic and non‐transgenic NOD mice

1998 • 5 citations

Adoptive transfer of islet antigen–autoreactive T cell clones to transgenic NOD.Eadmice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells

2003 • 3 citations

A panel of monoclonal antibodies to ovine placental lactogen

2000 • 3 citations

Effect of X‐ and Y‐Box Deletions on the Development of Diabetes in H‐2Eα‐Chain Transgenic Nonobese Diabetic Mice

2005 • 2 citations