Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

High-Resolution Profiling of Histone Methylations in the Human Genome

2007 • 6,479 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2003 • 6,017 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

Epigenetic differences arise during the lifetime of monozygotic twins

2005 • 3,451 citations

Genome-scale DNA methylation maps of pluripotent and differentiated cells

2008 • 2,432 citations

Environmental epigenomics and disease susceptibility

2007 • 2,387 citations

Combinatorial patterns of histone acetylations and methylations in the human genome

2008 • 2,214 citations

The Mammalian Epigenome

2007 • 1,977 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

2009 • 1,939 citations

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

2009 • 1,923 citations

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

2009 • 1,699 citations

Epigenetic reprogramming in mammals

2005 • 1,326 citations

Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

2007 • 1,321 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

2009 • 1,098 citations

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

2009 • 926 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Epigenetic Epidemiology of the Developmental Origins Hypothesis

2007 • 833 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

p38-dependent marking of inflammatory genes for increased NF-κB recruitment

2001 • 692 citations

Epigenetic control of T-helper-cell differentiation

2009 • 658 citations

Choline: Critical Role During Fetal Development and Dietary Requirements in Adults

2006 • 648 citations

RNA meets chromatin

2005 • 595 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Early Infant Feeding and Risk of Developing Type 1 Diabetes–Associated Autoantibodies

2003 • 567 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity

2003 • 519 citations

Environmental Triggers and Determinants of Type 1 Diabetes

2005 • 485 citations

Two Waves of Nuclear Factor κb Recruitment to Target Promoters

2001 • 386 citations

Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs

2003 • 384 citations

Chapter 1 Folate‐Mediated One‐Carbon Metabolism

2008 • 367 citations

Investigating stem cells in human colon by using methylation patterns

2001 • 356 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

2004 • 296 citations

Autoimmune mechanisms in type 1 diabetes

2008 • 251 citations

Interactions of NF-κB with chromatin: the art of being at the right place at the right time

2005 • 251 citations

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation

2008 • 244 citations

Relationship between β‐cell mass and diabetes onset

2008 • 232 citations

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans

2008 • 227 citations

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

2002 • 224 citations

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

2008 • 215 citations

Inhibition of IFN-γ transcription by site-specific methylation during T helper cell development

2006 • 210 citations

Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state

2007 • 204 citations

Age-Associated Activation of Epigenetically Repressed Genes in the Mouse

2003 • 196 citations

Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.

1998 • 194 citations

A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells

2006 • 182 citations

Genome-wide Analysis of Histone Lysine Methylation Variations Caused by Diabetic Conditions in Human Monocytes

2007 • 178 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study

1999 • 177 citations

Fidelity of the Methylation Pattern and Its Variation in the Genome

2003 • 166 citations

Effect of an inhibitor of DNA methylation on T cells. II. 5-azacytidine induces self-reactivity in antigen-specific T4+ cells

1986 • 149 citations

Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic β Cells

2003 • 141 citations

Hormonal Regulation of Cystathionine β-Synthase Expression in Liver

2002 • 141 citations

Taurine Supplementation of a Low Protein Diet Fed to Rat Dams Normalizes the Vascularization of the Fetal Endocrine Pancreas

2003 • 123 citations

DNA Methylation Is a Nonredundant Repressor of the Th2 Effector Program

2004 • 123 citations

Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

1995 • 113 citations

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

2008 • 112 citations

DNA Methylation Changes at Human Th2 Cytokine Genes Coincide with DNase I Hypersensitive Site Formation During CD4+ T Cell Differentiation

2002 • 110 citations

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

2007 • 105 citations

Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging.

1993 • 100 citations

Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation,S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation

2008 • 92 citations

Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription

2005 • 92 citations

Effects of a high-fat—sucrose diet on enzymes in homocysteine metabolism in the rat

2000 • 90 citations

Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice

2004 • 85 citations

A stepwise epigenetic process controls immunoglobulin allelic exclusion

2004 • 84 citations

Epigenetics and T-cell immunity

2008 • 82 citations

Epigenetics and T helper 1 differentiation

2008 • 80 citations

The T-box transcription factor T-bet in immunity and autoimmunity.

2006 • 79 citations

The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-β-synthase: studies in hepatocytes

2001 • 77 citations

The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression

2007 • 74 citations

Effect of DNA methylation and chromatin structure onITGAL expression

2002 • 71 citations

Dietary Proteins as Environmental Modifiers of Type 1 Diabetes Mellitus

2006 • 70 citations

Control of type 1 diabetes by CD4⁺Foxp3⁺ regulatory T cells: lessons from mouse models and implications for human disease

2009 • 65 citations

Reduced serum homocysteine levels in type 2 diabetes

2005 • 54 citations

Tubular complexes as a source for islet neogenesis in the pancreas of diabetes-prone BB rats

2005 • 53 citations

The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma.

1984 • 44 citations

Insulin Increases Homocysteine Levels in a Dose-Dependent Manner in Diabetic Rats

2002 • 32 citations

Effects of Insulin Deprivation and Treatment on Homocysteine Metabolism in People with Type 1 Diabetes

2006 • 31 citations

Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats

2007 • 24 citations

A low protein diet in early life delays the onset of diabetes in the non-obese diabetic mouse

2009 • 24 citations

The New Field Of Epigenomics: Implications for Cancer and Other Common Disease Research

2004 • 24 citations