Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

2002 • 260 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

2003 • 201 citations

Insulin as an autoantigen in NOD/human diabetes

2008 • 193 citations

The insulin secretory granule

1989 • 188 citations

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1993 • 182 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

Characterization and Quantitation of Peptide–MHC Complexes Produced from Hen Egg Lysozyme Using a Monoclonal Antibody

1997 • 169 citations

Proteomics Analysis of Insulin Secretory Granules

2007 • 151 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

Dendritic cells in islets of Langerhans constitutively present β cell-derived peptides bound to their class II MHC molecules

2008 • 128 citations

Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity

2007 • 103 citations

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

1999 • 103 citations

Analysis of the Spontaneous T Cell Response to Insulin in NOD Mice

1994 • 101 citations

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form

2007 • 100 citations

T Cells Distinguish MHC-Peptide Complexes Formed in Separate Vesicles and Edited by H2-DM

2004 • 88 citations

Unbiased analysis, enrichment and purification of thymic stromal cells

2007 • 86 citations

Pathogenic T‐Cell Clones in Autoimmune Diabetes: More Lessons from the NOD Mouse

2005 • 82 citations

pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH

1999 • 79 citations

Peptide and Major Histocompatibility Complex–Specific Breaking of Humoral Tolerance to Native Insulin With the B9-23 Peptide in Diabetes-Prone and Normal Mice

2001 • 69 citations

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout

2006 • 68 citations

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

2002 • 64 citations

Dual Overlapping Peptides Recognized by Insulin Peptide B:9–23 T Cell Receptor AV13S3 T Cell Clones of the NOD Mouse

2000 • 63 citations

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

2008 • 48 citations

Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion

2005 • 44 citations

APCs Present Aβk-Derived Peptides That Are Autoantigenic to Type B T Cells

2003 • 22 citations

HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules

1999 • 21 citations

Myelin-Reactive Type B T Cells and T Cells Specific for Low-Affinity MHC-Binding Myelin Peptides Escape Tolerance in HLA-DR Transgenic Mice

2008 • 21 citations

Culture of Dendritic Cells from a Nonlymphoid Organ, the Thyroid Gland: Evidence for TNFα-Dependent Phenotypic Changes of Thyroid-Derived Dendritic Cells

2000 • 14 citations

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