Insulin as an autoantigen in NOD/human diabetes

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 630 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺T cells in autoimmune diabetes

2003 • 378 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

2006 • 303 citations

Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

2005 • 275 citations

Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics

2004 • 271 citations

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

2002 • 260 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

2003 • 221 citations

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

2005 • 220 citations

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

2006 • 216 citations

Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

2004 • 212 citations

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

2003 • 210 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

2003 • 201 citations

Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

2004 • 195 citations

Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice

2002 • 195 citations

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

2007 • 193 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes

2007 • 181 citations

Pancreatic β-Cell Function and Immune Responses to Insulin After Administration of Intranasal Insulin to Humans At Risk for Type 1 Diabetes

2004 • 177 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Brief Communication: Early Appearance of Islet Autoantibodies Predicts Childhood Type 1 Diabetes in Offspring of Diabetic Parents

2004 • 150 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

2002 • 129 citations

Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide

2002 • 124 citations

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

2005 • 122 citations

Individual Nonobese Diabetic Mice Exhibit Unique Patterns of CD8+ T Cell Reactivity to Three Islet Antigens, Including the Newly Identified Widely Expressed Dystrophia Myotonica Kinase

2004 • 121 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1998 • 116 citations

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

2003 • 115 citations

Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity

2007 • 103 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form

2007 • 100 citations

T cell receptor restriction of diabetogenic autoimmune NOD T cells

1997 • 99 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

2005 • 85 citations

Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

1997 • 81 citations

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

2005 • 78 citations

Autoantibody markers for the diagnosis and prediction of type 1 diabetes

2005 • 74 citations

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

2000 • 71 citations

Peptide and Major Histocompatibility Complex–Specific Breaking of Humoral Tolerance to Native Insulin With the B9-23 Peptide in Diabetes-Prone and Normal Mice

2001 • 69 citations

Differential Immunogenetic Determinants of Polyclonal Insulin Autoimmune Syndrome (Hirata's Disease) and Monoclonal Insulin Autoimmune Syndrome

1995 • 69 citations

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout

2006 • 68 citations

Patients with Graves' disease who developed insulin autoimmune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406.

1993 • 63 citations

Dual Overlapping Peptides Recognized by Insulin Peptide B:9–23 T Cell Receptor AV13S3 T Cell Clones of the NOD Mouse

2000 • 63 citations

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

2004 • 61 citations

Autoimmune Diabetes Is Suppressed by Transfer of Proinsulin-Encoding Gr-1+ Myeloid Progenitor Cells That Differentiate In Vivo Into Resting Dendritic Cells

2005 • 60 citations

Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes

2006 • 57 citations

Update on Major Trials for the Prevention of Type I Diabetes Mellitus: The American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT)

2001 • 57 citations

TGF- signaling is required for the function of insulin-reactive T regulatory cells

2006 • 46 citations

Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives

2006 • 45 citations

Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child

2000 • 45 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 40 citations

Insulin Autoantibody Isotypes during the Prediabetic Process in Young Children with Increased Genetic Risk of Type 1 Diabetes

2003 • 38 citations

Altered B:9–23 Insulin, When Administered Intranasally with Cholera Toxin Adjuvant, Suppresses the Expression of Insulin Autoantibodies and Prevents Diabetes

2007 • 36 citations

Insulin allergy; desensitization with crystalline zinc-insulin and steroid tapering

2003 • 36 citations

Specific Human Leukocyte Antigen DQ Influence on Expression of Antiislet Autoantibodies and Progression to Type 1 Diabetes

2006 • 35 citations

Maternal Factors in a Model of Type 1 Diabetes Differentially Affect the Development of Insulitis and Overt Diabetes in Offspring

2005 • 25 citations

T Cell Epitope Mapping Study With Insulin Overlapping Peptides Using ELISPOT Assay in Japanese Children and Adolescents With Type 1 Diabetes

2006 • 21 citations

HLA Class I Epitope Discovery in Type 1 Diabetes

2006 • 21 citations

Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus

2001 • 17 citations

IgG₄‐mediated allergic reaction to glargine insulin

2006 • 11 citations

[Insulin allergy: background, diagnosis and treatment].

2005 • 11 citations