Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

1988 • 934 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

A Comparison of Childhood and Adult Type I Diabetes Mellitus

1989 • 278 citations

COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE-I DIABETES: POSSIBLE MONITORS OF ACTIVE BETA-CELL DAMAGE

1980 • 265 citations

[7] λgt 11: Gene isolation with antibody probes and other applications

1987 • 155 citations

Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement.

1992 • 147 citations

Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?

1986 • 146 citations

Insulin autoantibodies in the pre-diabetic period: Correlation with islet cell antibodies and development of diabetes

1986 • 124 citations

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

1992 • 97 citations

Expression of an enzymatically active parasite molecule in Escherichia coli: Schistosoma japonicum glutathione S-transferase

1988 • 77 citations

COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE-I DIABETES: POSSIBLE MONITORS OF ACTIVE BETA-CELL DAMAGE

1980 • 74 citations

Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment

1988 • 73 citations

Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?

1986 • 72 citations

Molecular autoimmunity

1992 • 64 citations

A New Chemical Aspect of Penicillin Allergy: The Direct Reaction of Penicillin with ɛ-Amino-Groups

1965 • 64 citations

Nucleotide Sequence of Human Preproinsulin Complementary DNA

1980 • 63 citations

Purification of recombinant antigenic epitopes of the human 68-kDa (U1) ribonucleoprotein antigen using the expression system pH6EX3 followed by metal chelating affinity chromatography

1992 • 55 citations

Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement

1992 • 51 citations

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

1988 • 41 citations

Production of recombinant rat interleukin-6 in Escherichia coli using a novel highly efficient expression vector pGEX-3T.

1992 • 33 citations

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function

1992 • 31 citations

Production of recombinant porcine tumor necrosis factor alpha in a novel E. coli expression system.

1992 • 19 citations

Determination of recombinant human proinsulin fusion protein produced in Escherichia coli using oxidative sulfitolysis and two-dimensional HPLC

1992 • 18 citations

Antibodies to Proinsulin and Insulin as Predictive Markers of Type 1 Diabetes

1990 • 16 citations