Slc11a1Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

2006 • 824 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

Natural Resistance to Intracellular Infections

2000 • 368 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility

1999 • 227 citations

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

1998 • 206 citations

Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter

2001 • 194 citations

Localisation of Nramp1 in macrophages: Modulation with activation and infection

1998 • 157 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

2003 • 149 citations

Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter

2001 • 138 citations

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

2006 • 125 citations

Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse

2004 • 111 citations

Genomic Structure, Promoter Sequence, and Induction of Expression of the Mouse Nramp1 Gene in Macrophages

1995 • 107 citations

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

1998 • 104 citations

A Sudden Decline in Active Membrane-Bound TGF-β Impairs Both T Regulatory Cell Function and Protection against Autoimmune Diabetes

2004 • 104 citations

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility

1996 • 101 citations

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

1998 • 84 citations

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

2005 • 84 citations

Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules

1997 • 79 citations

Subcongenic Analysis of theIdd13Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for β2-Microglobulin

1998 • 79 citations

Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules

1998 • 73 citations

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.

1998 • 69 citations

Slc11a1, Formerly Nramp1, Is Expressed in Dendritic Cells and Influences Major Histocompatibility Complex Class II Expression and Antigen-Presenting Cell Function

2007 • 66 citations

Interactions between Idd5.1/Ctla4 and Other Type 1 Diabetes Genes

2007 • 59 citations

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

2005 • 56 citations

Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter.

1997 • 50 citations

A Mutant Stat5b with Weaker DNA Binding Affinity Defines a Key Defective Pathway in Nonobese Diabetic Mice

2004 • 43 citations

Nonobese Diabetic Mouse Congenic Analysis Reveals Chromosome 11 Locus Contributing to Diabetes Susceptibility, Macrophage STAT5 Dysfunction, and Granulocyte-Macrophage Colony-Stimulating Factor Overproduction

2005 • 31 citations

Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1)

2004 • 26 citations

Biochemical Characterization of a Beta Cell Membrane Fraction Antigenic for Autoreactive T Cell Clones

2000 • 20 citations

I-Aβ gene expression regulation in macrophages derived from mice susceptible or resistant to infection with M. Bovis BCG

1997 • 20 citations

Loss of Invariant Chain Protects Nonobese Diabetic Mice against Type 1 Diabetes

2006 • 15 citations

The Molecular Context of a Determinant Influences Its Dominant Expression in a T Cell Response Hierarchy Through “Fine Processing”

1986 • 15 citations

N‐terminal flanking residues of a diabetes‐associated GAD65 determinant are necessary for activation of antigen‐specific T cells in diabetes‐resistant mice

2008 • 9 citations