Interferon alpha—a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity

Dendritic cells and the control of immunity

1998 • 14,345 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Viral hepatitis B

2003 • 1,771 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

IRF Family of Transcription Factors as Regulators of Host Defense

2001 • 1,566 citations

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2001 • 1,477 citations

Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus

2001 • 1,245 citations

Virus-Induced Diabetes Mellitus

1979 • 1,011 citations

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1979 • 907 citations

Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends

1999 • 906 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Early Infant Feeding and Risk of Developing Type 1 Diabetes–Associated Autoantibodies

2003 • 567 citations

Molecular Mimicry and Autoimmunity

1999 • 523 citations

Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity

2003 • 519 citations

A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon

1996 • 498 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Interferon α/β and Interleukin 12 Responses to Viral Infections

2002 • 473 citations

Side effects of high-dose interferon therapy for chronic hepatitis C

1996 • 469 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

A Prospective Study of the Role of Coxsackie B and Other Enterovirus Infections in the Pathogenesis of IDDM

1995 • 423 citations

Viral Antibodies in Diabetes Mellitus

1969 • 413 citations

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

1995 • 369 citations

The role of viruses in human diabetes

2002 • 309 citations

Induction of Type I Diabetes by Interferon-α in Transgenic Mice

1993 • 289 citations

A new look at viruses in type 1 diabetes

2002 • 264 citations

A missing link in the hygiene hypothesis?

2002 • 246 citations

Interferon Expression in the Pancreases of Patients With Type I Diabetes

1995 • 244 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a

1995 • 237 citations

Generation of Interferon α–Producing Predendritic Cell (Pre-Dc)2 from Human Cd34+ Hematopoietic Stem Cells

2000 • 230 citations

The First Signs of β-Cell Autoimmunity Appear in Infancy in Genetically Susceptible Children from the General Population: The Finnish Type 1 Diabetes Prediction and Prevention Study

2001 • 215 citations

Target cell defense prevents the development of diabetes after viral infection

2002 • 213 citations

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile.

1994 • 211 citations

Coxsackie Viruses and Diabetes Mellitus

1973 • 205 citations

Persistent Infection of Human Pancreatic Islets by Coxsackievirus B Is Associated with Alpha Interferon Synthesis in β Cells

2000 • 188 citations

Immunostimulation circumvents diabetes in NODLt mice

1989 • 182 citations

Increased Level of Interferon‐α in Blood of Patients with Insulin‐Dependent Diabetes Mellitus: Relationship with Coxsackievirus B Infection

2000 • 179 citations

TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide

1994 • 179 citations

Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study

1999 • 177 citations

Congenital rubella syndrome as a model for Type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies

1984 • 156 citations

The role of viruses in Type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals

2001 • 151 citations

Enterovirus RNA Is Found in Peripheral Blood Mononuclear Cells in a Majority of Type 1 Diabetic Children at Onset

2002 • 144 citations

Effect of Interferon on Glucose Tolerance and Insulin Sensitivity

1989 • 144 citations

Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM

1995 • 139 citations

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

2002 • 129 citations

Viruses and Diabetes

2002 • 125 citations

Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy

2003 • 120 citations

A Case of Diabetes Mellitus Quickly Following Mumps

1899 • 108 citations

Secular Trends in Incidence of Childhood IDDM in 10 Countries

1990 • 104 citations

Prospective study of enteroviral infections and development of beta-cell autoimmunity

2002 • 98 citations

IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2.

1996 • 96 citations

Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with Type I diabetes: The German BABYDIAB study

1999 • 96 citations

Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report

2000 • 92 citations

Incidence of insulin dependent diabetes in England: a study in the Oxford region, 1985-6.

1989 • 88 citations

Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases

2003 • 86 citations

Autoimmune aspects of cytokine and anticytokine therapies

2003 • 82 citations

Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice

1994 • 79 citations

T-cell responses to enterovirus antigens in children with type 1 diabetes.

2000 • 77 citations

Incidence of Type 1 (insulin-dependent) diabetes mellitus in Catalonia, Spain

1992 • 76 citations

Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.

1994 • 75 citations

Complete nucleotide sequence of a strain of coxsackie B4 virus of human origin that induces diabetes in mice and its comparison with nondiabetogenic coxsackie B4 JBV strain

1994 • 73 citations

Poly I:C Induces Development of Diabetes Mellitus in BB Rat

1992 • 73 citations

Antibodies to Glutamic Acid Decarboxylase and P2-C Peptides in Sera From Coxsackie Virus B4-Infected Mice and IDDM Patients

1994 • 71 citations

Interferon induces insulin resistance in patients with chronic active hepatitis C

1998 • 69 citations

The Epidemiology of Type 1 Diabetes in Children in Philadelphia 1990–1994

2002 • 61 citations

Juvenile diabetes as a sequel to mumps

1947 • 54 citations

Islet cell and thyroid antibody prevalence in patients with hepatitis C virus infection: Effect of treatment with interferon

2001 • 52 citations

A new look at viruses in type 1 diabetes

1995 • 50 citations

Disease-Associated Autoantibodies as Surrogate Markers of Type 1 Diabetes in Young Children at Increased Genetic Risk¹

2000 • 49 citations

Cytotoxic effect of IFN-γ plus TNF-α on human islet cells

1991 • 48 citations

Ingested interferon α suppresses Type I diabetes in non-obese diabetic mice

1998 • 47 citations

Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

1998 • 47 citations

Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice

2002 • 47 citations

Pulmonary side effects of interferon‐α therapy in patients with hematological malignancies

2003 • 43 citations

Inhibitory Effect of Interferon on the Production of Insulin

1985 • 42 citations

High incidence of autoimmune alterations in chronic myeloid leukemia patients treated with interferon‐α

2003 • 39 citations

Nomenclature of the Human Interferon Genes^a

1996 • 39 citations

Vogt‐Koyanagi‐Harada disease associated with interferon alpha‐2b/ribavirin combination therapy

2003 • 38 citations

Gastric autoimmune disorders in patients with chronic hepatitis C before, during and after interferon-alpha therapy

2003 • 33 citations

The Antiviral 2′,5′-Oligoadenylate Synthetase Is Persistently Activated in Type 1 Diabetes

2000 • 32 citations

Simultaneous onset of Type 1 diabetes mellitus in identical infant twins with enterovirus infection

1998 • 30 citations

Ingested IFN-αPreserves ResidualβCell Function in Type 1 Diabetes

2001 • 25 citations

Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets

1984 • 23 citations

Complete nucleotide sequence of a beta‐cell tropic variant of coxsackievirus B4

1994 • 23 citations

Ingested Type I Interferon: A Potential Treatment for Autoimmunity

2002 • 21 citations

Differential Responsiveness to Interferon-α in β-Cells and Non-β-Cells

1996 • 20 citations

The Production of Immunoreactive α‐and γ‐Interferon by Circulating Mononuclear Cells in Type 1 Diabetes

1991 • 10 citations

Familial juvenile-onset diabetes.

1977 • 10 citations

Deleted Work

1955 • 0 citations