The myofibroblast: Paradigm for a mechanically active cell

Matrix Elasticity Directs Stem Cell Lineage Specification

2006 • 12,751 citations

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

2005 • 5,909 citations

Wound repair and regeneration

2008 • 5,291 citations

Foreign body reaction to biomaterials

2008 • 4,431 citations

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

2005 • 4,328 citations

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Environmental sensing through focal adhesions

2008 • 2,342 citations

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

2004 • 2,220 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

The Myofibroblast

2007 • 1,901 citations

Myotubes differentiate optimally on substrates with tissue-like stiffness

2004 • 1,629 citations

Structural Basis of Integrin Regulation and Signaling

2007 • 1,575 citations

Nonlinear elasticity in biological gels

2005 • 1,568 citations

Formation and Function of the Myofibroblast during Tissue Repair

2007 • 1,508 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Stretching Single Talin Rod Molecules Activates Vinculin Binding

2009 • 1,415 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL

2003 • 1,286 citations

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

2007 • 1,215 citations

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

2001 • 1,207 citations

Activation of Integrin Function by Nanopatterned Adhesive Interfaces

2004 • 1,143 citations

Systemic sclerosis: a prototypic multisystem fibrotic disorder

2007 • 1,072 citations

Renal fibrosis: New insights into the pathogenesis and therapeutics

2006 • 1,029 citations

The role of matrix stiffness in regulating cell behavior

2008 • 979 citations

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

2006 • 907 citations

Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands

2007 • 894 citations

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

2006 • 880 citations

The relationship between force and focal complex development

2002 • 876 citations

Adhesion-Dependent Cell Mechanosensitivity

2003 • 847 citations

Histology for Pathologists

1992 • 820 citations

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

2008 • 819 citations

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

2007 • 817 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

The tumour microenvironment as a target for chemoprevention

2007 • 790 citations

Tensile forces govern germ-layer organization in zebrafish

2008 • 766 citations

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

2008 • 762 citations

Mechanisms of Pulmonary Fibrosis

2004 • 714 citations

Matrices with Compliance Comparable to that of Brain Tissue Select Neuronal over Glial Growth in Mixed Cortical Cultures

2006 • 705 citations

Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets

2006 • 697 citations

Mechanically Activated Integrin Switch Controls α ₅ β ₁ Function

2009 • 690 citations

Stromal myofibroblasts are drivers of invasive cancer growth

2008 • 681 citations

Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

2006 • 673 citations

Demonstration of catch bonds between an integrin and its ligand

2009 • 662 citations

Visualizing the mechanical activation of Src

2005 • 658 citations

THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure

2005 • 628 citations

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

2007 • 611 citations

Cell Mechanics: Integrating Cell Responses to Mechanical Stimuli

2007 • 605 citations

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

2001 • 605 citations

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

2004 • 543 citations

INTEGRIN STRUCTURE, ALLOSTERY, AND BIDIRECTIONAL SIGNALING

2005 • 528 citations

Mechanotransduction at Cell-Matrix and Cell-Cell Contacts

2004 • 520 citations

Actin’ together: serum response factor, its cofactors and the link to signal transduction

2006 • 514 citations

Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation

2007 • 501 citations

The Myofibroblast in Pulmonary Fibrosis*

2002 • 498 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

2008 • 480 citations

The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts

1999 • 462 citations

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

2004 • 459 citations

The structure and regulation of vinculin

2006 • 449 citations

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

2006 • 448 citations

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

2003 • 435 citations

Cell Adhesion Strengthening: Contributions of Adhesive Area, Integrin Binding, and Focal Adhesion Assembly

2005 • 413 citations

Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus

2002 • 408 citations

Cardiac fibroblasts: friend or foe?

2006 • 395 citations

Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

2005 • 387 citations

Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize

2006 • 372 citations

Forced Unfolding of Proteins Within Cells

2007 • 371 citations

Marching at the front and dragging behind

2001 • 358 citations

Evaluation of polydimethylsiloxane scaffolds with physiologically-relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response

2004 • 350 citations

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

2009 • 336 citations

The role of proteases in transforming growth factor-β activation

2008 • 319 citations

Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway

2007 • 313 citations

Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury

2006 • 298 citations

α-Smooth Muscle Actin Is Crucial for Focal Adhesion Maturation in Myofibroblasts

2003 • 297 citations

Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors

2001 • 296 citations

Focal adhesions as mechanosensors: A physical mechanism

2005 • 292 citations

Force transduction by Triton cytoskeletons

2002 • 289 citations

The mechanical integrin cycle

2008 • 282 citations

Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission

2005 • 271 citations

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells

2002 • 270 citations

Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

2009 • 267 citations

Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

2006 • 266 citations

Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts

2003 • 262 citations

Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow

2008 • 252 citations

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

2009 • 251 citations

Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling

2002 • 247 citations

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

2002 • 226 citations

Cell mechanosensitivity controls the anisotropy of focal adhesions

2004 • 224 citations

The Role of Matrix Stiffness in Hepatic Stellate Cell Activation and Liver Fibrosis

2005 • 221 citations

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

2005 • 216 citations

Histological analysis of silicone breast implant capsules and correlation with capsular contracture

2002 • 208 citations

Keloid or Hypertrophic Scar

2005 • 193 citations

Integrin-mediated activation of latent transforming growth factor β

2005 • 193 citations

How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation

2006 • 191 citations

Simultaneous Stretching and Contraction of Stress Fibers In Vivo

2004 • 191 citations

Histology for Pathologists

2008 • 189 citations

Mechanical strain increases type I collagen expression in pulmonary fibroblasts in vitro

2000 • 171 citations

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

2004 • 167 citations

A Conformational Switch in Vinculin Drives Formation and Dynamics of a Talin-Vinculin Complex at Focal Adhesions

2006 • 158 citations

Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL

2004 • 150 citations

Activation of Fibroblast Procollagen α1(I) Transcription by Mechanical Strain Is Transforming Growth Factor-β-dependent and Involves Increased Binding of CCAAT-binding Factor (CBF/NF-Y) at the Proximal Promoter

2002 • 147 citations

MYOFIBROBLASTS AND FREE SILICON AROUND BREAST IMPLANTS

1978 • 135 citations

From the membrane to the nucleus and back again: bifunctional focal adhesion proteins

2006 • 133 citations

Latent TGF‐β1 activation by platelets

2003 • 118 citations

Force-Induced Adsorption and Anisotropic Growth of Focal Adhesions

2006 • 114 citations

Transforming Growth Factor-β1 Specifically Induce Proteins Involved in the Myofibroblast Contractile Apparatus

2004 • 114 citations

Membrane and acto-myosin tension promote clustering of adhesion proteins

2004 • 110 citations

Limitation of Cell Adhesion by the Elasticity of the Extracellular Matrix

2006 • 107 citations

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL

2008 • 105 citations

Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer

2006 • 103 citations

CELLULAR STRUCTURE AND BIOLOGY OF DUPUYTREN’S DISEASE

1999 • 101 citations

The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.

1995 • 82 citations

Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod^,

2006 • 77 citations

Expression and function of α-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation

2006 • 75 citations

Dynamics of Cellular Focal Adhesions on Deformable Substrates: Consequences for Cell Force Microscopy

2008 • 59 citations

Biology of the scleroderma fibroblast

1998 • 58 citations

Phalloidin Binding and Rheological Differences among Actin Isoforms

1996 • 56 citations

Cell–Matrix Adhesions on Poly(vinyl alcohol) Hydrogels

2003 • 51 citations

Flux at Focal Adhesions: Slippage Clutch, Mechanical Gauge, or Signal Depot

2007 • 50 citations

Transcriptional Regulation of a Contractile Gene by Mechanical Forces Applied through Integrins in Osteoblasts

2002 • 48 citations

The N-terminal Ac-EEED sequence plays a role in α-smooth-muscle actin incorporation into stress fibers

2005 • 46 citations

Regenerative medicine and biomaterials for the repair of connective tissues

2010 • 44 citations

Elevation of transforming growth factor beta (TGFβ) and its downstream mediators in subcutaneous foreign body capsule tissue

2007 • 40 citations

Association of fibroblast orientation around titanium in vitro with expression of a muscle actin

2000 • 24 citations

Cell adhesion and signaling

2008 • 13 citations

The myofibroblast - friend or foe in regenerative medicine?

2008 • 1 citations