Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

2005 • 5,909 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Movement Is Guided by the Rigidity of the Substrate

2000 • 3,179 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

2004 • 2,220 citations

Local force and geometry sensing regulate cell functions

2006 • 2,178 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Cells lying on a bed of microneedles: An approach to isolate mechanical force

2003 • 1,919 citations

Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape.

1993 • 1,765 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Cellular mechanotransduction: putting all the pieces together again

2006 • 1,528 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Activation of Integrin Function by Nanopatterned Adhesive Interfaces

2004 • 1,143 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

2006 • 880 citations

The relationship between force and focal complex development

2002 • 876 citations

Adhesion-Dependent Cell Mechanosensitivity

2003 • 847 citations

Mechanisms of Mechanotransduction

2006 • 746 citations

Integrins in Mechanotransduction

2004 • 690 citations

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

2003 • 658 citations

Visualizing the mechanical activation of Src

2005 • 658 citations

A possible unifying principle for mechanosensation

2005 • 657 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment

2001 • 547 citations

Conformational Regulation of Integrin Structure and Function

2002 • 536 citations

Focal adhesion kinase is involved in mechanosensing during fibroblast migration

2001 • 485 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Cell distribution of stress fibres in response to the geometry of the adhesive environment

2006 • 442 citations

Substrate Rigidity Regulates the Formation and Maintenance of Tissues

2005 • 437 citations

MECHANOTRANSDUCTION INVOLVING MULTIMODULAR PROTEINS: Converting Force into Biochemical Signals

2006 • 433 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Exploring the Neighborhood

2002 • 398 citations

Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts

2004 • 395 citations

Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

2005 • 387 citations

Structural basis for vinculin activation at sites of cell adhesion

2004 • 371 citations

Is the Mechanical Activity of Epithelial Cells Controlled by Deformations or Forces?

2005 • 363 citations

Myosin 2 Is a Key Rho Kinase Target Necessary for the Local Concentration of E-Cadherin at Cell–Cell Contacts

2005 • 358 citations

Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension

2002 • 355 citations

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly

2005 • 351 citations

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression

2002 • 340 citations

The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation

2005 • 330 citations

Staying in Shape with Formins

2006 • 322 citations

Activation of a Signaling Cascade by Cytoskeleton Stretch

2004 • 303 citations

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

2002 • 301 citations

Integrin activation takes shape

2002 • 299 citations

Focal adhesions as mechanosensors: A physical mechanism

2005 • 292 citations

Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response

2006 • 273 citations

Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

2006 • 266 citations

Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors

2004 • 263 citations

Dealing with mechanics: mechanisms of force transduction in cells

2004 • 254 citations

Molecular details of formin-mediated actin assembly

2005 • 246 citations

Vinculin activation by talin through helical bundle conversion

2003 • 238 citations

Rigidity Sensing at the Leading Edge through αvβ3 Integrins and RPTPα

2005 • 230 citations

Assembly and mechanosensory function of focal adhesions: experiments and models

2005 • 225 citations

Cell mechanosensitivity controls the anisotropy of focal adhesions

2004 • 224 citations

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

2005 • 216 citations

Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

2003 • 216 citations

How do microtubules guide migrating cells?

2002 • 202 citations

Components of cell-matrix adhesions

2001 • 200 citations

RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkages

2003 • 199 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Structure and functional significance of mechanically unfolded fibronectin type III ₁ intermediates

2003 • 194 citations

Cellular Responses to Substrate Topography: Role of Myosin II and Focal Adhesion Kinase

2006 • 184 citations

Assembly and Reorientation of Stress Fibers Drives Morphological Changes to Endothelial Cells Exposed to Shear Stress

2004 • 171 citations

Focal adhesions as mechanosensors: The two-spring model

2005 • 171 citations

Focal adhesions: What's new inside

2006 • 166 citations

Talin: an emerging focal point of adhesion dynamics

2003 • 165 citations

Roles of Rho-associated Kinase and Myosin Light Chain Kinase in Morphological and Migratory Defects of Focal Adhesion Kinase-null Cells

2002 • 151 citations

Mechanical Unfolding Intermediates Observed by Single-molecule Force Spectroscopy in a Fibronectin Type III Module

2004 • 139 citations

Elastic interactions of active cells with soft materials

2004 • 121 citations

Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

1994 • 121 citations

Processive capping by formin suggests a force-driven mechanism of actin polymerization

2004 • 120 citations

Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase

2001 • 118 citations

Force-Induced Adsorption and Anisotropic Growth of Focal Adhesions

2006 • 114 citations

Fibronectin Rigidity Response through Fyn and p130Cas Recruitment to the Leading Edge

2006 • 114 citations

Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow

2006 • 112 citations

Limitation of Cell Adhesion by the Elasticity of the Extracellular Matrix

2006 • 107 citations

Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility

2006 • 105 citations

Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer

2006 • 103 citations

Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow

2005 • 102 citations

Cooperativity between Cell Contractility and Adhesion

2004 • 86 citations

Force-induced focal adhesion translocation: effects of force amplitude and frequency

2004 • 80 citations

Purified Integrin Adhesion Complexes Exhibit Actin-Polymerization Activity

2006 • 78 citations

Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly

2004 • 77 citations

Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod^,

2006 • 77 citations

Theory of Force Regulation by Nascent Adhesion Sites

2005 • 77 citations

Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stress

2004 • 64 citations

Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells

2006 • 53 citations

Force-induced unfolding of the focal adhesion targeting domain and the influence of paxillin binding.

2004 • 42 citations

Calyculin‐A induces focal adhesion assembly and tyrosine phosphorylation of p125^Fak, p130^Cas, and paxillin in Swiss 3T3 cells

2001 • 33 citations

Shear‐Stress Profile along a Cell Focal Adhesion

2006 • 26 citations

Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery

2006 • 21 citations