A Conformational Switch in Vinculin Drives Formation and Dynamics of a Talin-Vinculin Complex at Focal Adhesions

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

1976 • 2,658 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

2004 • 1,330 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

2003 • 1,168 citations

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

1999 • 697 citations

Calpain-mediated proteolysis of talin regulates adhesion dynamics

2004 • 534 citations

Vinculin knockout results in heart and brain defects during embryonic development

1998 • 511 citations

Structural Determinants of Integrin Recognition by Talin

2003 • 505 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells

2001 • 439 citations

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

2003 • 435 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Structural basis for vinculin activation at sites of cell adhesion

2004 • 371 citations

The mechanisms and dynamics of αvβ3 integrin clustering in living cells

2005 • 332 citations

Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides

2001 • 316 citations

A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices.

1982 • 310 citations

Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture.

1985 • 293 citations

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility

2004 • 256 citations

Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling

2004 • 247 citations

Vinculin activation by talin through helical bundle conversion

2003 • 238 citations

Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain

2001 • 219 citations

Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

2003 • 216 citations

Analysis of Cell Mechanics in Single Vinculin-Deficient Cells Using a Magnetic Tweezer

2000 • 216 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

The inner lives of focal adhesions

2002 • 206 citations

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

1995 • 203 citations

Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod

2005 • 197 citations

The ActA protein of Listeria monocytogenes acts as a nucleator inducing reorganization of the actin cytoskeleton.

1994 • 188 citations

Spatial distribution and functional significance of activated vinculin in living cells

2005 • 182 citations

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

2004 • 167 citations

Two Distinct Head-Tail Interfaces Cooperate to Suppress Activation of Vinculin by Talin

2005 • 167 citations

Fluorescence photobleaching analysis for the study of cellular dynamics

2002 • 132 citations

The Vinculin Binding Sites of Talin and α-Actinin Are Sufficient to Activate Vinculin

2006 • 123 citations

Vinculin acts as a sensor in lipid regulation of adhesion-site turnover

2005 • 116 citations

A Vinculin Binding Domain from the Talin Rod Unfolds to Form a Complex with the Vinculin Head

2005 • 108 citations

Intact Vinculin Protein Is Required for Control of Cell Shape, Cell Mechanics, and rac-Dependent Lamellipodia Formation

2002 • 105 citations

Structural Dynamics of α-Actinin-Vinculin Interactions

2005 • 93 citations

Phosphoinositide Binding Regulates α-Actinin Dynamics

2005 • 83 citations

Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod^,

2006 • 77 citations

Microfilament‐dependent movement of the β3 integrin subunit within focal contacts of endothelial cells

2002 • 69 citations

Further characterization of the interaction between the cytoskeletal proteins talin and vinculin

2002 • 59 citations

The Activity of the Vinculin Binding Sites in Talin Is Influenced by the Stability of the Helical Bundles That Make Up The Talin Rod

2006 • 52 citations

Further characterization of the interaction between the cytoskeletal proteins talin and vinculin

2002 • 38 citations