Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Data up to Jan 2025
Total Citations Per Year
Abstract
References (56)
Myofibroblasts and mechano-regulation of connective tissue remodelling
2002 • 3,938 citations
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 • 3,650 citations
A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1
1999 • 1,965 citations
The Myofibroblast
2007 • 1,901 citations
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.
1986 • 1,644 citations
Making sense of latent TGFβ activation
2002 • 1,579 citations
The myofibroblast in wound healing and fibrocontractive diseases
2003 • 1,548 citations
Formation and Function of the Myofibroblast during Tissue Repair
2007 • 1,508 citations
Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity
2001 • 1,207 citations
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
2006 • 1,197 citations
The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1
1998 • 801 citations
An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct
1994 • 749 citations
Mechanisms of Pulmonary Fibrosis
2004 • 714 citations
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1
2002 • 701 citations
Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers
2006 • 673 citations
Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation
2001 • 605 citations
Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly
1998 • 589 citations
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.
1991 • 509 citations
The Myofibroblast in Pulmonary Fibrosis*
2002 • 498 citations
The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts
1999 • 462 citations
Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
2004 • 459 citations
TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences
1990 • 447 citations
The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
2004 • 445 citations
MECHANOTRANSDUCTION INVOLVING MULTIMODULAR PROTEINS: Converting Force into Biochemical Signals
2006 • 433 citations
Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β
1997 • 397 citations
Latent TGF-β Binding Proteins: Extracellular Matrix Association and Roles in TGF-β Activation
2004 • 346 citations
Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
2007 • 298 citations
Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury
2006 • 298 citations
α-Smooth Muscle Actin Is Crucial for Focal Adhesion Maturation in Myofibroblasts
2003 • 297 citations
Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors
2001 • 296 citations
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways
2006 • 266 citations
BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein
2006 • 247 citations
Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts
2005 • 233 citations
Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1
1998 • 229 citations
The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo
2002 • 226 citations
Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts
2005 • 217 citations
Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin.
1992 • 204 citations
Integrin-mediated activation of latent transforming growth factor β
2005 • 193 citations
Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts
2006 • 161 citations
Quantifying Lamella Dynamics of Cultured Cells by SACED, a New Computer-Assisted Motion Analysis
1999 • 132 citations
The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
2003 • 119 citations
Latent TGF-β binding protein LTBP-1 contains three potential extracellular matrix interacting domains
2001 • 106 citations
Expression of the Integrin α8β1 during Pulmonary and Hepatic Fibrosis
2000 • 104 citations
αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts
2004 • 98 citations
Active Transforming Growth Factor-β in Wound Repair
1999 • 96 citations
Upregulation of TGF-β1 Expression May Be Necessary but Is Not Sufficient for Excessive Scarring
2006 • 84 citations
The Cutaneous Microfibrillar Apparatus Contains Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) and is a Repository for Latent TGF-β1
1998 • 83 citations
TGF-β activation by traction?
2004 • 82 citations
Integrin α8β1 mediates adhesion to LAP-TGFβ1
2002 • 78 citations
Integrin-Mediated Transforming Growth Factor-β Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit
2006 • 75 citations
Contractile activity and smooth muscle α-actin organization in thrombin-induced human lung myofibroblasts
2003 • 69 citations
Extracellular regulation of TGF-β activity in wound repair: growth factor latency as a sensor mechanism for injury
2004 • 67 citations
α8β1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium
2003 • 60 citations
Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma.
1997 • 60 citations
Sequential deposition of latent TGF-β binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts
2005 • 54 citations
Transforming growht factor β1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma
1997 • 13 citations
Cited By (0)
No citing papers found in database