Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks

The Hallmarks of Cancer

2000 • 27,569 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

2005 • 4,715 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

2002 • 2,139 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

2005 • 1,364 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

2006 • 1,252 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

2001 • 1,206 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Biallelic Inactivation of BRCA2 in Fanconi Anemia

2002 • 1,138 citations

Discontinuities in the DNA synthesized in an Excision-defective strain of Escherichia coli following ultraviolet irradiation

1968 • 1,089 citations

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

2002 • 1,081 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

The importance of repairing stalled replication forks

2000 • 1,054 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

2003 • 1,045 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

2005 • 972 citations

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

2006 • 965 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

The Fanconi anaemia/BRCA pathway

2003 • 819 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

2002 • 805 citations

Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

2006 • 802 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

2003 • 767 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

2001 • 691 citations

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

2002 • 679 citations

RecQ helicases: caretakers of the genome

2003 • 676 citations

Initiation of genetic recombination and recombination-dependent replication

2000 • 675 citations

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

2002 • 671 citations

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

2001 • 655 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

2006 • 632 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

2006 • 615 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain

2004 • 556 citations

DNA Repair and Genetic Recombination: Studies on Mutants of Escherichia coli Defective in These Processes

1966 • 554 citations

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

2000 • 548 citations

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

2006 • 547 citations

Silencing of unsynapsed meiotic chromosomes in the mouse

2004 • 546 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

RuvAB Acts at Arrested Replication Forks

1998 • 533 citations

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

1997 • 531 citations

Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair

2004 • 514 citations

Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break

2004 • 503 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

2004 • 473 citations

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

2001 • 471 citations

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

2006 • 459 citations

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

2005 • 449 citations

Characteristics of γ-H2AX foci at DNA double-strand breaks sites

2003 • 442 citations

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1997 • 426 citations

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

2001 • 420 citations

RecFOR Proteins Load RecA Protein onto Gapped DNA to Accelerate DNA Strand Exchange

2003 • 416 citations

EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer

2003 • 416 citations

BRCA1, Histone H2AX Phosphorylation, and Male Meiotic Sex Chromosome Inactivation

2004 • 409 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

1999 • 403 citations

Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication.

1996 • 397 citations

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

2004 • 391 citations

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

1998 • 383 citations

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

2001 • 379 citations

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

2001 • 357 citations

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

1999 • 351 citations

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

2003 • 350 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

Multiple pathways process stalled replication forks

2004 • 324 citations

Making Sense of Eukaryotic DNA Replication Origins

2001 • 316 citations

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1999 • 315 citations

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction

2005 • 315 citations

Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2

2004 • 314 citations

Replication fork reactivation downstream of a blocked nascent leading strand

2006 • 313 citations

Pathways for mitotic homologous recombination in mammalian cells

2003 • 313 citations

The Fanconi Anaemia Gene FANCC Promotes Homologous Recombination and Error-Prone DNA Repair

2004 • 311 citations

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

2006 • 305 citations

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

2002 • 302 citations

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

2003 • 291 citations

Brca2 is required for embryonic cellular proliferation in the mouse.

1997 • 285 citations

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

2003 • 278 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

2006 • 274 citations

Replisome assembly and the direct restart of stalled replication forks

2006 • 268 citations

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

2002 • 260 citations

Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

2005 • 260 citations

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

2004 • 255 citations

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

1997 • 253 citations

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

2002 • 252 citations

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

2001 • 251 citations

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

2003 • 243 citations

Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing

2003 • 243 citations

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

2004 • 241 citations

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

2004 • 239 citations

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

2003 • 239 citations

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

1997 • 236 citations

Break-induced replication: A review and an example in budding yeast

2001 • 232 citations

Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo

2003 • 217 citations

Chromosome Break-Induced DNA Replication Leads to Nonreciprocal Translocations and Telomere Capture

1998 • 215 citations

The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression

2001 • 210 citations

An Age-Induced Switch to a Hyper-Recombinational State

2003 • 205 citations

Control of Sister Chromatid Recombination by Histone H2AX

2004 • 205 citations

Functional Interaction of BRCA1-Associated BARD1 with Polyadenylation Factor CstF-50

1999 • 194 citations

RAD51-Dependent Break-Induced Replication in Yeast

2004 • 187 citations

Interaction between the Product of the Breast Cancer Susceptibility Gene BRCA2 and DSS1, a Protein Functionally Conserved from Yeast to Mammals

1999 • 180 citations

Chromosomal Translocation Mechanisms at Intronic Alu Elements in Mammalian Cells

2005 • 174 citations

XRCC3 Controls the Fidelity of Homologous Recombination

2002 • 171 citations

RAD51-Dependent Break-Induced Replication Differs in Kinetics and Checkpoint Responses from RAD51-Mediated Gene Conversion

2005 • 168 citations

BRCA2 Homolog Required for Proficiency in DNA Repair, Recombination, and Genome Stability in Ustilago maydis

2002 • 167 citations

Gaps and forks in DNA replication: Rediscovering old models

2006 • 160 citations

Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

2003 • 155 citations

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

2005 • 149 citations

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites

2006 • 148 citations

BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

2004 • 144 citations

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

2001 • 141 citations

The INO80 Protein Controls Homologous Recombination in Arabidopsis thaliana

2004 • 140 citations

ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair

2002 • 136 citations

Role of DNA Replication Proteins in Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

2004 • 129 citations

BRCA1 RING Domain Cancer-predisposing Mutations

2001 • 127 citations

Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis

1997 • 123 citations

Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide

2006 • 121 citations

Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks

2003 • 119 citations

Dynamic Control of Rad51 Recombinase by Self-Association and Interaction with BRCA2

2003 • 119 citations

The BRCA2-Interacting Protein DSS1 Is Vital for DNA Repair, Recombination, and Genome Stability in Ustilago maydis

2003 • 112 citations

The RecA Binding Locus of RecBCD Is a General Domain for Recruitment of DNA Strand Exchange Proteins

2006 • 111 citations

Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation.

1995 • 110 citations

Evidence for Multiple Cycles of Strand Invasion During Repair of Double-Strand Gaps in Drosophila

2004 • 107 citations

Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand 1 1Edited by M. Yaniv

1999 • 104 citations

Characterization of Arabidopsis thaliana ortholog of the human breast cancer susceptibility gene 1: AtBRCA1, strongly induced by gamma rays

2003 • 89 citations

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

2006 • 84 citations

A mechanism of palindromic gene amplification in Saccharomyces cerevisiae

2005 • 84 citations

Fine-resolution mapping of spontaneous and double-strand break-induced gene conversion tracts in Saccharomyces cerevisiae reveals reversible mitotic conversion polarity.

1994 • 82 citations

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

2006 • 80 citations

A role for Brca1 in chromosome end maintenance

2006 • 76 citations

Role of BRCAgene dysfunction in breast and ovarian cancer predisposition

2000 • 76 citations

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

2000 • 70 citations

The RAD52 Recombinational Repair Pathway is Essential in pol30 (PCNA) Mutants That Accumulate Small Single-Stranded DNA Fragments During DNA Synthesis

1998 • 67 citations

Differential Regulation of Short- and Long-Tract Gene Conversion between Sister Chromatids by Rad51C

2006 • 64 citations

A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants

2006 • 57 citations

Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes

2006 • 56 citations

Effects of Terminal Nonhomology and Homeology on Double-Strand-Break-Induced Gene Conversion Tract Directionality

1996 • 29 citations

Fine-Resolution Mapping of Spontaneous and Double-Strand Break-Induced Gene Conversion Tracts in Saccharomyces cerevisiae Reveals Reversible Mitotic Conversion Polarity

1994 • 29 citations

Replication of simian virus 40 DNA after UV irradiation: evidence of growing fork blockage and single-stranded gaps in daughter strands

1988 • 28 citations

Junctions on the road to cancer

2004 • 14 citations