A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

C. elegans: des neurones et des gènes

2003 • 3,047 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

2005 • 1,034 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

H2AX: the histone guardian of the genome

2004 • 978 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

A Conserved Checkpoint Pathway Mediates DNA Damage–Induced Apoptosis and Cell Cycle Arrest in C. elegans

2000 • 506 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

2001 • 471 citations

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

2001 • 357 citations

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

1999 • 351 citations

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

2002 • 349 citations

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

2003 • 340 citations

CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis

2005 • 327 citations

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

2002 • 302 citations

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

2003 • 291 citations

Combined Functional Genomic Maps of the C. elegans DNA Damage Response

2002 • 279 citations

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

2003 • 278 citations

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

2002 • 274 citations

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

2004 • 255 citations

Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans

2003 • 239 citations

Histone H2A Phosphorylation Controls Crb2 Recruitment at DNA Breaks, Maintains Checkpoint Arrest, and Influences DNA Repair in Fission Yeast

2004 • 194 citations

Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans

2005 • 169 citations

C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G₂ DNA damage checkpoint

2001 • 152 citations

BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

2004 • 144 citations

BRCA1 RING Domain Cancer-predisposing Mutations

2001 • 127 citations

New complexities for BRCA1 and BRCA2

2001 • 115 citations

Down-regulation of BRCA1-BARD1 Ubiquitin Ligase by CDK2

2005 • 64 citations

Identification of Residues Required for the Interaction of BARD1 with BRCA1

2002 • 39 citations

ATM and ATR

2003 • 36 citations

Tandem immunoaffinity purification of protein complexes from Caenorhabditis elegans

2004 • 34 citations

Caenorhabditis elegansUBC-2 functions with the anaphase-promoting complex but also has other activities

2004 • 10 citations