Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Meiotic Chromosomes: Integrating Structure and Function

1999 • 1,250 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Recombinational DNA double-strand breaks in mice precede synapsis

2001 • 853 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Meiotic chromosomes: it takes two to tango

1997 • 810 citations

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1996 • 800 citations

The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis

2000 • 772 citations

Histone H2A variants H2AX and H2AZ

2002 • 749 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

The Mouse RecA-like Gene Dmc1 Is Required for Homologous Chromosome Synapsis during Meiosis

1998 • 568 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

2000 • 447 citations

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

1999 • 423 citations

Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction

1994 • 386 citations

The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination

2002 • 383 citations

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

2001 • 379 citations

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

2001 • 359 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1996 • 318 citations

Roles of BRCA1 and its interacting proteins

2000 • 318 citations

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

2002 • 302 citations

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

2003 • 289 citations

Direct DNA binding by Brca1

2001 • 277 citations

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I

1998 • 270 citations

Developmentally Regulated Expression of a Mouse Germ Cell Nuclear Antigen Examined from Embryonic Day 11 to Adult in Male and Female Mice

1994 • 269 citations

Rad51 and Dmc1 Form Mixed Complexes Associated with Mouse Meiotic Chromosome Cores and Synaptonemal Complexes

1999 • 240 citations

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

2002 • 234 citations

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

1999 • 229 citations

The p53 pathway and apoptosis

1999 • 222 citations

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

1995 • 200 citations

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

1999 • 198 citations

The Rad51 and Dmc1 recombinases: a non-identical twin relationship

2001 • 159 citations

Breast Cancer Susceptibility Genes: BRCA1 and BRCA2

1998 • 158 citations

BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

2002 • 157 citations

BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks

2002 • 149 citations

TIP49b, a New RuvB-like DNA Helicase, Is Included in a Complex Together with Another RuvB-like DNA Helicase, TIP49a

1999 • 144 citations

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

2002 • 133 citations

Tumorigenesis in mice carrying a truncating Brca1 mutation

2001 • 129 citations

Epidemiology, prevention, and early detection of breast cancer

1996 • 118 citations

Regulation of meiotic recombination and prophase I progression in mammals

2001 • 116 citations

Meiotic Prophase Abnormalities and Metaphase Cell Death in MLH1-Deficient Mouse Spermatocytes: Insights into Regulation of Spermatogenic Progress

2002 • 109 citations

Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

2001 • 107 citations

BRCA1 Is a Selective Co-activator of 14-3-3ς Gene Transcription in Mouse Embryonic Stem Cells

2001 • 100 citations

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining

2002 • 96 citations

BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation

2002 • 82 citations

Emerging roles of BRCA1 in transcriptional regulation and DNA repair

1999 • 77 citations

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

2001 • 58 citations

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

2001 • 52 citations

Epidemiology, prevention, and early detection of breast cancer

1997 • 46 citations

Brcal: A Review of Structure and Putative Functions

1998 • 44 citations

BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.

1996 • 38 citations

Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes

2001 • 35 citations

Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

2003 • 32 citations