H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

Surfing the p53 network

2000 • 6,487 citations

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

H2AX: the histone guardian of the genome

2004 • 978 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation

2002 • 734 citations

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

2002 • 653 citations

A role for Saccharomyces cerevisiae histone H2A in DNA repair

2000 • 647 citations

Mechanisms of chromosomal translocations in B cell lymphomas

2001 • 623 citations

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

2006 • 601 citations

H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis

2003 • 582 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

2002 • 529 citations

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 • 496 citations

Histone H2AX

2003 • 479 citations

DNA damage checkpoint control in cells exposed to ionizing radiation

2003 • 478 citations

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

2005 • 452 citations

AID Is Required for c-myc/IgH Chromosome Translocations In Vivo

2004 • 449 citations

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

2003 • 404 citations

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

2003 • 354 citations

The role of DNA breaks in genomic instability and tumorigenesis

2003 • 352 citations

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

2004 • 325 citations

53BP1 is required for class switch recombination

2004 • 316 citations

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

2000 • 315 citations

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

2002 • 306 citations

Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences

2005 • 296 citations

The histone code at DNA breaks: a guide to repair?

2005 • 292 citations

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

2003 • 277 citations

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

2005 • 276 citations

DNA sequences at immunoglobulin switch region recombination sites

1993 • 275 citations

HIF-1: A Target For Cancer, Ischemia and Inflammation—Too Good to be True?

2004 • 251 citations

ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions

2004 • 209 citations

Control of Sister Chromatid Recombination by Histone H2AX

2004 • 205 citations

Aid

2004 • 191 citations

Molecular Biology of B Cells

2015 • 188 citations

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

2005 • 174 citations

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

2000 • 170 citations

H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity

2004 • 169 citations

Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

2004 • 167 citations

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

2001 • 159 citations

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

2005 • 143 citations

Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability

2003 • 134 citations

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1

2005 • 132 citations

Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination.

1997 • 122 citations

Nibrin functions in Ig class-switch recombination

2005 • 104 citations

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S in Ig class switch recombination

2004 • 95 citations

Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination

2005 • 87 citations

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

2002 • 86 citations

Molecular Biology of B Cells

2004 • 86 citations

The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region

2003 • 85 citations

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis

2006 • 77 citations

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc

2004 • 72 citations

Immunoglobulin Heavy Chain Genes of Mouse

2004 • 18 citations