Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

2005 • 1,209 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

2005 • 1,034 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Mechanism and regulation of human non-homologous DNA end-joining

2003 • 957 citations

ATR and ATRIP: Partners in Checkpoint Signaling

2001 • 935 citations

Choreography of the DNA Damage Response

2004 • 881 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

2005 • 579 citations

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

2002 • 556 citations

DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain

2004 • 556 citations

Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair

2004 • 514 citations

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway

2004 • 507 citations

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

2002 • 476 citations

Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

2004 • 466 citations

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

2003 • 463 citations

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

1997 • 438 citations

PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

2004 • 433 citations

Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre

2003 • 421 citations

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

2005 • 417 citations

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

2004 • 395 citations

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

2004 • 374 citations

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

1999 • 348 citations

The cellular response to DNA double-strand breaks: defining the sensors and mediators

2003 • 336 citations

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

2004 • 334 citations

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

2006 • 305 citations

The histone code at DNA breaks: a guide to repair?

2005 • 292 citations

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

2005 • 276 citations

Specific Recruitment of Human Cohesin to Laser-induced DNA Damage

2002 • 249 citations

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage

2002 • 248 citations

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

2005 • 242 citations

Rad51 Accumulation at Sites of DNA Damage and in Postreplicative Chromatin

2000 • 213 citations

UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress

2004 • 204 citations

Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex

2004 • 198 citations

Chk1 in the DNA damage response: conserved roles from yeasts to mammals

2004 • 192 citations

Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response

2005 • 183 citations

Mediator of DNA Damage Checkpoint Protein 1 Regulates BRCA1 Localization and Phosphorylation in DNA Damage Checkpoint Control

2003 • 136 citations

Inhibition of Chk1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation

2004 • 98 citations

Imaging of protein movement induced by chromosomal breakage: tiny ‘local’ lesions pose great ‘global’ challenges

2005 • 98 citations

Interplay between chromatin and cell cycle checkpoints in the context of ATR/ATM-dependent checkpoints

2004 • 65 citations

Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair

2002 • 63 citations