Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer

1999 • 866 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2

2002 • 809 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

1998 • 695 citations

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

2001 • 691 citations

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

2002 • 679 citations

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

2002 • 671 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Involvement of Brca1 in S-Phase and G₂-Phase Checkpoints after Ionizing Irradiation

2001 • 537 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

BRCA1 is a component of the RNA polymerase II holoenzyme

1997 • 450 citations

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1999 • 421 citations

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

2001 • 420 citations

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

1998 • 392 citations

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1998 • 389 citations

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

1999 • 351 citations

Roles of BRCA1 and its interacting proteins

2000 • 318 citations

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

2000 • 315 citations

Brca2 is required for embryonic cellular proliferation in the mouse.

1997 • 285 citations

Direct DNA binding by Brca1

2001 • 277 citations

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

2002 • 260 citations

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

2002 • 252 citations

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

2001 • 251 citations

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

2000 • 217 citations

Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control

1999 • 201 citations

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

1999 • 198 citations

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

1999 • 192 citations

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

2001 • 186 citations

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1998 • 183 citations

Chromosomal Double-Strand Breaks Induce Gene Conversion at High Frequency in Mammalian Cells

1997 • 173 citations

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

2000 • 148 citations

A Human BRCA2 Complex Containing a Structural DNA Binding Component Influences Cell Cycle Progression

2001 • 141 citations

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

1999 • 106 citations

Coping with replication ‘train wrecks’ in Escherichia coli using Pol V, Pol II and RecA proteins

2000 • 105 citations

The Fuss about Mus81

2001 • 94 citations

Developmental studies of Brca1 and Brca2 knock-out mice.

1998 • 84 citations

Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain

1999 • 83 citations

A Derivative of an Ataxia-telangiectasia (A-T) Cell Line with Normal Radiosensitivity but A-T-like Inhibition of DNA Synthesis

1985 • 70 citations

BRCA1 signals ARF-dependent stabilization and coactivation of p53

1999 • 68 citations

BRCA1 and BRCA2 - breast cancer susceptibility genes

2000 • 43 citations

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase

2000 • 25 citations

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

2000 • 22 citations

Involvement ofBRCA1 andBRCA2 in breast cancer in a western Finnish sub-population

2001 • 11 citations

BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription

2000 • 10 citations