TLP, a novel modulator of TGF- signaling, has opposite effects on Smad2- and Smad3-dependent signaling

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

SMART: a web-based tool for the study of genetically mobile domains

2000 • 1,298 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Smad regulation in TGF-β signal transduction

2001 • 917 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

2001 • 638 citations

TGF-β signaling by Smad proteins

2000 • 618 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TGF-β signaling by Smad proteins

2000 • 406 citations

Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

2001 • 397 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

2001 • 350 citations

Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes

2002 • 320 citations

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

2002 • 304 citations

TGFβ receptor internalization into EEA1-enriched early endosomes

2002 • 298 citations

Disabled‐2 Colocalizes with the LDLR in Clathrin‐Coated Pits and Interacts with AP‐2

2001 • 262 citations

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

2001 • 246 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

1995 • 196 citations

Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway

2002 • 187 citations

Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

2000 • 176 citations

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

2000 • 174 citations

STRAP and Smad7 Synergize in the Inhibition of Transforming Growth Factor β Signaling

2000 • 171 citations

Vam2/Vps41p and Vam6/Vps39p Are Components of a Protein Complex on the Vacuolar Membranes and Involved in the Vacuolar Assembly in the Yeast Saccharomyces cerevisiae

1997 • 171 citations

Smad3 and Smad4 Mediate Transcriptional Activation of the Human Smad7 Promoter by Transforming Growth Factor β

2000 • 167 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Human Vam6p promotes lysosome clustering and fusion in vivo

2001 • 152 citations

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF‐β/Smad signalling

2002 • 150 citations

Clathrin self-assembly is mediated by a tandemly repeated superhelix

1999 • 147 citations

Early Endosomal Regulation of Smad-dependent Signaling in Endothelial Cells

2002 • 143 citations

Physical and Functional Interactions between Type I Transforming Growth Factor β Receptors and Bα, a WD-40 Repeat Subunit of Phosphatase 2A

1998 • 127 citations

Transforming Growth Factor-β Receptors Interact with AP2 by Direct Binding to β2 Subunit

2002 • 127 citations

Prediction of the Coding Sequences of Unidentified Human Genes. XVII. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro

2000 • 124 citations

Transforming Growth Factor-β Receptor-associated Protein 1 Is a Smad4 Chaperone

2001 • 93 citations

Stoichiometry of Active Smad-Transcription Factor Complexes on DNA

2002 • 90 citations

Transforming growth factors β

1989 • 86 citations

Endofin, an Endosomal FYVE Domain Protein

2001 • 73 citations

A Novel Protein Distinguishes between Quiescent and Activated Forms of the Type I Transforming Growth Factor β Receptor

1998 • 71 citations

SARA, a FYVE domain protein, affects Rab5-mediated endocytosis

2002 • 67 citations

The endocytic machinery at an interface with the actin cytoskeleton: a dynamic, hip intersection

2002 • 65 citations

Heteromeric and Homomeric Transforming Growth Factor-β Receptors Show Distinct Signaling and Endocytic Responses in Epithelial Cells

1998 • 50 citations

Smad3 Inhibits Transforming Growth Factor-β and Activin Signaling by Competing with Smad4 for FAST-2 Binding

1999 • 38 citations

Alternatively spliced variant of smad2 lacking exon 3 : comparison with wild-type smad2 and smad3

2001 • 13 citations