SMART: a web-based tool for the study of genetically mobile domains

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The Pfam protein families database.

2002 • 14,298 citations

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids

2005 • 3,777 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

Membrane protein structure prediction

1992 • 1,680 citations

The Pfam Protein Families Database

2000 • 1,235 citations

The PROSITE database, its status in 1999

1999 • 1,109 citations

[33] Analysis of compositionally biased regions in sequence databases

1996 • 768 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

Eukaryotic Signalling Domain Homologues in Archaea and Bacteria. Ancient Ancestry and Horizontal Gene Transfer

1999 • 328 citations

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1999 • 325 citations

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

1998 • 256 citations

Sequence properties of GPI-anchored proteins near the omega-site: constraints for the polypeptide binding site of the putative transamidase

1998 • 246 citations

Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs

1997 • 237 citations

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.

1999 • 234 citations

Domains in plexins: links to integrins and transcription factors

1999 • 204 citations

The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor

1999 • 163 citations

Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery

1999 • 112 citations

SH3 domains in prokaryotes

1999 • 111 citations

Two-domain reconstitution of a functional protein histidine kinase

1998 • 102 citations

Evolution of domain families

2000 • 101 citations

Protein annotation: detective work for function prediction

1998 • 74 citations

The FF domain: a novel motif that often accompanies WW domains

1999 • 73 citations

Protein families in multicellular organisms

1999 • 68 citations

Cloning and developmental expression of pea ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit N-methyltransferase

1995 • 51 citations

The PWI motif: a new protein domain in splicing factors

1999 • 28 citations