Stoichiometry of Active Smad-Transcription Factor Complexes on DNA

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

Crystal Structure of a Phosphorylated Smad2

2001 • 295 citations

Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

2000 • 292 citations

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

2001 • 291 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus

2000 • 266 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm

1998 • 250 citations

Regulation of Smad signalling by protein associations and signalling crosstalk

1999 • 248 citations

Ski/Sno and TGF-β signaling

2001 • 192 citations

Smad3 and Smad4 Mediate Transcriptional Activation of the Human Smad7 Promoter by Transforming Growth Factor β

2000 • 167 citations

Efficient TGF-β Induction of the Smad7 Gene Requires Cooperation between AP-1, Sp1, and Smad Proteins on the Mouse Smad7 Promoter

2000 • 155 citations

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.

2001 • 141 citations

Participation of Smad2, Smad3, and Smad4 in Transforming Growth Factor β (TGF-β)-induced Activation of Smad7

2000 • 137 citations

Smad3 allostery links TGF-β receptor kinase activation to transcriptional control

2002 • 136 citations

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

1997 • 129 citations

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

2000 • 121 citations

Distinct Oligomeric States of SMAD Proteins in the Transforming Growth Factor-β Pathway

2000 • 118 citations

Structural insights on Smad function in TGFβ signaling

2001 • 116 citations

The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis

1999 • 111 citations

Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter

2000 • 108 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes

1999 • 92 citations

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

2002 • 91 citations

Formation of a Stable Heterodimer between Smad2 and Smad4

2001 • 85 citations

Repression of transforming-growth-factor-β-mediated transcription by nuclear factor κB

2000 • 80 citations

Synergism between Transcription Factors TFE3 and Smad3 in Transforming Growth Factor-β-induced Transcription of theSmad7 Gene

2000 • 69 citations

Crystal structure of a transcriptionally active Smad4 fragment

1999 • 64 citations

Sedimentation Studies Reveal a Direct Role of Phosphorylation in Smad3:Smad4 Homo- and Hetero-Trimerization

2001 • 56 citations

A novelXenopusSmad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements

2002 • 41 citations