Disabled‐2 Colocalizes with the LDLR in Clathrin‐Coated Pits and Interacts with AP‐2

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Current Protocols in Molecular Biology

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Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

1999 • 902 citations

Reelin Is a Ligand for Lipoprotein Receptors

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CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process

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Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

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Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

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Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

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Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

1998 • 576 citations

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

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Developmental selection of var gene expression in Plasmodium falciparum

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Identification of two lysosomal membrane glycoproteins.

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Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

2000 • 458 citations

Linking cargo to vesicle formation: receptor tail interactions with coat proteins

1997 • 408 citations

Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning

1999 • 407 citations

The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

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Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

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AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis

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The role of clathrin, adaptors and dynamin in endocytosis

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Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module

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Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain

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Eps15 Is a Component of Clathrin-coated Pits and Vesicles and Is Located at the Rim of Coated Pits

1996 • 266 citations

eps15, a novel tyrosine kinase substrate, exhibits transforming activity.

1993 • 265 citations

Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development

2000 • 258 citations

The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals

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Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

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Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis

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Quantification of low density lipoprotein and transferrin endocytic sorting in HEp2 cells using confocal microscopy

1994 • 212 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1

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The Epsins Define a Family of Proteins That Interact with Components of the Clathrin Coat and Contain a New Protein Module

1999 • 186 citations

The Ear of α-Adaptin Interacts with the COOH-terminal Domain of the Eps15 Protein

1996 • 186 citations

Molecular Cloning of Differentially Expressed Genes in Human Epithelial Ovarian Cancer

1994 • 183 citations

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer

1998 • 182 citations

Crystal structure of the α appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly

1999 • 180 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 162 citations

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

1993 • 157 citations

The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor

1995 • 137 citations

Cloning of a Novel Phosphoprotein Regulated by Colony-stimulating Factor 1 Shares a Domain with the Drosophiladisabled Gene Product

1995 • 136 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

Disabled-2 inactivation is an early step in ovarian tumorigenicity

1999 • 134 citations

Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin

1997 • 124 citations

Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.

1993 • 123 citations

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

1998 • 119 citations

The Very Low Density Lipoprotein Receptor Regulates Urokinase Receptor Catabolism and Breast Cancer Cell Motility in Vitro

1999 • 103 citations

Endocytosis proteins and cancer: a potential link?

1998 • 103 citations

Regulation of Rat DOC-2 Gene during Castration-Induced Rat Ventral Prostate Degeneration and Its Growth Inhibitory Function in Human Prostatic Carcinoma Cells*

1998 • 99 citations

DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

1998 • 97 citations

Coat Proteins Regulating Membrane Traffic

1999 • 95 citations

The LDL Receptor Clustering Motif Interacts with the Clathrin Terminal Domain in a Reverse Turn Conformation

1998 • 92 citations

Mapping of the molecular determinants involved in the interaction between eps15 and AP-2.

1997 • 92 citations

EH: a novel protein-protein interaction domain potentially involved in intracellular sorting

1997 • 84 citations

Direct interaction of the 170 kDa isoform of synaptojanin 1 with clathrin and with the clathrin adaptor AP-2

2000 • 78 citations

Calcium Phosphate Transfection

1997 • 68 citations

The Role of DOC-2/DAB2 Protein Phosphorylation in the Inhibition of AP-1 Activity

1999 • 61 citations

p96, a MAPK-related protein, is consistently downregulated during mouse mammary carcinogenesis

1998 • 55 citations

Endocytosis: An assembly protein for clathrin cages

1999 • 52 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 40 citations

Disabled Is a Putative Adaptor Protein That Functions during Signaling by the Sevenless Receptor Tyrosine Kinase

1998 • 28 citations