Selective iNOS Inhibition Is Superior to Norepinephrine in the Treatment of Rat Endotoxic Shock

Nitric oxide synthases in mammals

1994 • 2,762 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Endogenous nitric oxide: physiology, pathology and clinical relevance

1991 • 766 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1996 • 576 citations

Laboratory models of sepsis and septic shock

1990 • 539 citations

Multiple Organ Failure Syndrome in the 1990s

1994 • 532 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Reevaluation of the Role of Cellular Hypoxia and Bioenergetic Failure in Sepsis

1992 • 383 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Alterations in nitric oxide production in various forms of circulatory shock.

1995 • 321 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors.

1995 • 308 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury

1992 • 274 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock

1995 • 256 citations

Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite

1996 • 254 citations

Skeletal muscle partial pressure of oxygen in patients with sepsis

1994 • 238 citations

The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

1995 • 219 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

The non specificity of specific nitric oxide synthase inhibitors

1992 • 176 citations

Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia

1992 • 172 citations

Nitric oxide and septic shock.

1996 • 159 citations

The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine

1992 • 157 citations

Inhibition of Nitric Oxide Synthesis Is Detrimental During Endotoxemia

1994 • 151 citations

NG-Monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock

1991 • 147 citations

Potent and Selective Inhibition of Human Nitric Oxide Synthases

1994 • 136 citations

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

1995 • 134 citations

L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo

1989 • 126 citations

Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion

1995 • 125 citations

Inhibition of Nitric Oxide Synthesis Causes Myocardial Ischemia in Endotoxemic Rats

1995 • 122 citations

Nitric Oxide and Septic Shock

1996 • 118 citations

Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update

1994 • 116 citations

Detrimental Hemodynamic Effects of Nitric Oxide Synthase Inhibition in Septic Shock

1994 • 115 citations

Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia

1985 • 114 citations

Attenuation of endotoxin‐induced multiple organ dysfunction by 1‐amino‐2‐hydroxy‐guanidine, a potent inhibitor of inducible nitric oxide synthase

1996 • 110 citations

Inhibition of Nitric Oxide Synthase in Experimental Gram-Negative Sepsis

1994 • 94 citations

Prevention of the Expression of Inducible Nitric Oxide Synthase by Aminoguanidine or Aminoethyl-Isothiourea in Macrophages and in the Rat

1996 • 80 citations

Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion.

1994 • 80 citations

Cellular mechanisms of endotoxin-induced myocardial depression in rabbits.

1993 • 74 citations

Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone

1992 • 74 citations

A SELECTIVE INHIBITOR OF INDUCIBLE NITRIC OXIDE SYNTHASE PROLONGS SURVIVAL IN A RAT MODEL OF BACTERIAL PERITONITIS

1996 • 73 citations

Cellular oxygen metabolism during sepsis and shock. The relationship of oxygen consumption to oxygen delivery.

1988 • 71 citations

Role of nitric oxide in porcine liver circulation under normal and endotoxemic conditions

1995 • 67 citations

Cellular Oxygen Metabolism During Sepsis and Shock

1988 • 67 citations

NG-monomethyl-l-arginine causes nitric oxide synthesis in isolated arterial rings: Trouble in paradise

1992 • 66 citations

Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform

1996 • 58 citations

Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs

1995 • 56 citations

Beneficial Effects of L-Canavanine, a Selective Inhibitor of Inducible Nitric Oxide Synthase, during Rodent Endotoxaemia

1996 • 49 citations

Nitric Oxide Inhibition in the Treatment of the Sepsis Syndrome Is Detrimental to Tissue Oxygenation

1994 • 47 citations

L-canavanine improves organ function and tissue adenosine triphosphate levels in rodent endotoxemia.

1997 • 45 citations

Role of Nitric Oxide Pathway in the Protection Against Lethal Endotoxemia Afforded by Low Doses of Lipopolysaccharide

1993 • 41 citations

Cardiorespiratory and tissue oxygen dose response to rat endotoxemia

1996 • 32 citations

Measurement of cardiac output in small animals by aortic thermodilution

1982 • 32 citations

Vascular pharmacology of methylene blue in vitro and in vivo: a comparison with N^G‐nitro‐<scp>l</scp>‐arginine and diphenyleneiodonium

1995 • 28 citations

L-canavanine, an inhibitor of inducible nitric oxide synthase, improves venous return in endotoxemic rats

1997 • 26 citations

Nitric oxide and the gut

1999 • 17 citations

Nitric oxide, myocardial failure and septic shock

1995 • 13 citations

Attenuation of arteriolar alpha 2-adrenoceptor sensitivity during endotoxemia

1994 • 11 citations