Nitric oxide and septic shock.

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 • 585 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis

1994 • 450 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

1994 • 320 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

L-arginine pathway in the sepsis syndrome

1993 • 242 citations

Differential Expression of iNOS and cNOS mRNA in Human Vascular Smooth Muscle Cells and Endothelial Cells under Normal and Inflammatory Conditions

1993 • 238 citations

Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia

1992 • 172 citations

Inhibition of Nitric Oxide Synthesis Is Detrimental During Endotoxemia

1994 • 151 citations

NG-Monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock

1991 • 147 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats

1997 • 142 citations

Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils.

1994 • 134 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

Role of nitric oxide in the hemodynamic changes of sepsis

1993 • 124 citations

Detrimental Hemodynamic Effects of Nitric Oxide Synthase Inhibition in Septic Shock

1994 • 115 citations

Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity.

1994 • 107 citations

Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia

1994 • 106 citations

Inhibition of Nitric Oxide Synthase in Experimental Gram-Negative Sepsis

1994 • 94 citations

Does Endothelium-Derived Nitric Oxide Have a Rolein Cytokine-Induced Hypotension?

1990 • 89 citations

Inhibition of NO synthesis in septic shock

1992 • 84 citations

Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion.

1994 • 80 citations

Inhibition of Interleukin-1- -Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1- -Induced Hypotension by N -Amino-L-arginine

1992 • 76 citations

Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone

1992 • 74 citations

N sup G-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension

1995 • 66 citations

Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function

1991 • 66 citations

Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs

1995 • 56 citations

Inhibition of Nitric Oxide Synthesis Improves the Vasoconstrictive Effect of Noradrenaline in Sepsis

1994 • 55 citations

Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock

1995 • 54 citations

Dissection of vertebral artery after cervical trauma

1992 • 54 citations

Nitric Oxide Inhibition in the Treatment of the Sepsis Syndrome Is Detrimental to Tissue Oxygenation

1994 • 47 citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs

1994 • 41 citations

Difference in Pressor Responses to NG-Monomethyl-L-Arginine between Conscious and Anesthetized Rats.

1991 • 27 citations

Effect of combined nitric oxide inhalation and N sup G-nitro-L-arginine infusion in porcine endotoxin shock

1995 • 26 citations

Effects of Halothane Anesthesia on Vasoconstrictor Response to NG-Nitro-L-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Synthesis, in Sheep

1993 • 22 citations

Is Endotoxin-lnduced Hypotension Related to Nitric Oxide Formation?

1994 • 19 citations

Cardiovascular effects of NG-methyl-L-arginine in chronically instrumented conscious dogs

1994 • 16 citations

Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis

1995 • 3 citations