Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Inhibition of nitric oxide synthesis by methylene blue

1993 • 519 citations

The high-output nitric oxide pathway: role and regulation

1994 • 512 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase

1994 • 464 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Aminoguanidine selectively inhibits inducible nitric oxide synthase

1993 • 412 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Alterations in nitric oxide production in various forms of circulatory shock.

1995 • 321 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase

1995 • 306 citations

Nitric oxide and arthritis

1993 • 299 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

1993 • 289 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine

1993 • 274 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Identification of N‐iminoethyl‐<scp>l</scp>‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

1991 • 258 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline.

1994 • 220 citations

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

1994 • 216 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

Aminoguanidine Is an Isoform-Selective, Mechanism-Based Inactivator of Nitric Oxide Synthase

1995 • 191 citations

INVITED OPINION

1994 • 185 citations

Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis

1981 • 182 citations

The non specificity of specific nitric oxide synthase inhibitors

1992 • 176 citations

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell <scp>l</scp>‐arginine transporter

1992 • 172 citations

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

1991 • 166 citations

Prokaryotic Expression of the Heme- and Flavin-Binding Domains of Rat Neuronal Nitric Oxide Synthase as Distinct Polypeptides: Identification of the Heme-Binding Proximal Thiolate Ligand as Cysteine-415

1995 • 163 citations

Effects of guanidino and uremic compounds on nitric oxide pathways

1994 • 161 citations

Inhibition of Constitutive and Inducible Nitric Oxide Synthase: Potential Selective Inhibition

1995 • 157 citations

The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine

1992 • 157 citations

Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.

1994 • 155 citations

Inhibition of nitric oxide formation by guanidines

1993 • 154 citations

The Discovery of Nitric Oxide in the Vessel Wall

1993 • 150 citations

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

1991 • 148 citations

Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta

1994 • 143 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Aggression and emotional development.

1948 • 141 citations

Time‐dependent enhancement or inhibition of endotoxin‐induced vascular injury in rat intestine by nitric oxide synthase inhibitors

1994 • 137 citations

Potent and Selective Inhibition of Human Nitric Oxide Synthases

1994 • 136 citations

Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo

1995 • 131 citations

Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

1983 • 131 citations

Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole

1994 • 131 citations

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation

1993 • 130 citations

Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.

1994 • 128 citations

Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

1994 • 117 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits

1994 • 116 citations

Chemical Protection against Ionizing Radiation: III. Mercaptoalkylguanidines and Related Isothiuronium Compounds with Protective Activity

1957 • 112 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

The influence of catabolic reactions on polyamine excretion

1985 • 110 citations

Nitric Oxide Synthesis and the Effect of Aminoguanidine and NG-monomethyl-<scp>L</scp>-Arginine on the Onset of Diabetes in the Spontaneously Diabetic BB Rat

1995 • 107 citations

Synthesis of L-Thiocitrulline, L-Homothiocitrulline, and S-Methyl-L-thiocitrulline: A New Class of Potent Nitric Oxide Synthase Inhibitors

1994 • 107 citations

On the mechanism of the nitric oxide synthase-catalyzed conversion of N omega-hydroxyl-L-arginine to citrulline and nitric oxide.

1994 • 106 citations

L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases

1994 • 98 citations

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1991 • 91 citations

Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles

1993 • 88 citations

Inhibition of constitutive endothelial nosynthase activity by tannin and quercetin

1995 • 78 citations

The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation

1994 • 74 citations

Essential Role for Nitric Oxide in Neurogenic Inflammation in Rat Cutaneous Microcirculation

1995 • 71 citations

NG-monomethyl-l-arginine causes nitric oxide synthesis in isolated arterial rings: Trouble in paradise

1992 • 66 citations

The Inhibition of the Constitutive Bovine Endothelial Nitric Oxide Synthase by Imidazole and Indazole Agents

1994 • 65 citations

Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta.

1992 • 64 citations

Characterization of the Inactivation of Nitric Oxide Synthase by NG-Methyl-L-arginine: Evidence for Heme Loss

1994 • 63 citations

Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin Levels and the Role of the Cofactor in Tyrosine Hydroxylation in Primary Cultures of Adrenomedullary Chromaffin Cells

1986 • 61 citations

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis

1992 • 57 citations

In vivo radiation protection by nitric oxide modulation.

1994 • 52 citations

Modular Structure of Neuronal Nitric Oxide Synthase: Localization of the Arginine Binding Site and Modulation by Pterin

1995 • 50 citations

Structure-activity relationships of amidine derivatives.

1962 • 44 citations

Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform

1995 • 44 citations

Nitric Oxide Production Depends on Preceding Tetrahydrobiopterin Synthesis by Endothelial Cells: Selective Suppression of Induced Nitric Oxide Production by Sepiapterin Reductase Inhibitors

1994 • 42 citations

In vitro and ex vivo inhibitory effects of L- and D-enantiomers of NG-nitro-arginine on endothelium-dependent relaxation of rat aorta.

1993 • 37 citations

Selective inhibition of basal but not agonist‐stimulated activity of nitric oxide in rat aorta by N^G‐monomethyl‐<scp>l</scp>‐arginine

1993 • 36 citations

Aminoguanidine, An Inhibitor of Nitric Oxide Formation, Fails to Protect Against Insulitis and Hyperglycemia Induced by Multiple Low Dose Streptozotocin Injections in Mice

1993 • 36 citations

Guanidinium derivatives act as high affinity antagonists of Na+ ions in occlusion sites of Na+,K(+)-ATPase.

1992 • 34 citations

Effect of Nitric Oxide Synthase Substrate Analog Inhibitors on Rat Liver Arginase

1993 • 34 citations

Inhibition of Purified Nitric Oxide Synthase from Rat Cerebellum and Macrophage by L-Arginine Analogs

1994 • 33 citations

Tetrahydrobiopterin Turnover in Cultured Rat Sympathetic Neurons: Developmental Profile, Pharmacologic Sensitivity, and Relationship to Norepinephrine Synthesis

1992 • 32 citations

First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.

1995 • 32 citations

Stimulation of hepatocyte System y(+)-mediated L-arginine transport by an inflammatory agent.

1992 • 31 citations

Phencyclidine, a Psychotomimetic Agent and Drug of Abuse, Is a Suicide Inhibitor of Brain Nitric Oxide Synthase

1993 • 29 citations

Inhibition by N‐acetyl‐5‐hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat

1995 • 28 citations

Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro

1994 • 28 citations

The biology of nitric oxide 3. Physiological and clinical aspects

1995 • 26 citations

3-Amino-1,2,4-triazole inhibits macrophage no synthase

1992 • 25 citations

The nitric oxide synthase inhibitor NW-Nitro-L-Arginine methylester attenuates brain catalase activity in vitro

1995 • 22 citations

The circulatory effects of some iso‐thiourea derivatives, with special reference to the sensitization of animals to the pressor action of adrenaline

1943 • 21 citations

2-Iminobiotin Is an Inhibitor of Nitric Oxide Synthases

1994 • 20 citations

α‐Guanidinoglutaric Acid, an Endogenous Convulsant, as a Novel Nitric Oxide Synthase Inhibitor

1994 • 17 citations

Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain

1994 • 17 citations

Circulatory properties of iso-thioureas, guanidines, iso-ureas and amidines.

1947 • 13 citations

Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase.

1994 • 13 citations

Cationic amino acids inhibit the effects of L-arginine in rat aorta exposed to lipopolysaccharide

1993 • 12 citations

N-Acetylserotonin prevents the hypotension induced by bacterial lipopolysaccharides in the rat

1993 • 12 citations

Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages

1992 • 11 citations

Circulatory properties of iso-thioureas, guanidines, iso-ureas and amidines

1947 • 10 citations

Structure-activity Relationship of Alkylguanidines on Smooth Muscle Organs

1968 • 8 citations

Metabolism and radioprotective effect of AET and MEG in organism.

1973 • 6 citations

S-METHYLISOTHIOUREA SULPHATE FOR MAINTAINING BLOOD-PRESSURE IN SPINAL ANESTHESIA

1942 • 3 citations

234 A NEW NON-AMINO ACID INHIBITOR OF NITRIC OXIDE SYNTHASE (3936W92) IN HYPERDYNAMIC OVINE SEPSIS

1995 • 2 citations

DEVELOPMENT OF A SELECTIVE INHIBITOR OF CYTOKINE-INDUCIBLE L-ARGININE TRANSPORT (CNI-1493) THAT BLOCKS MACROPHAGE PRODUCTION OF NO, and TNFa, and PROTECTS AGAINST LPS LETHALITY

1995 • 2 citations

S-methylisothiourea Sulphate for Maintaining Blood-pressure in Spinal Anaesthesia

1943 • 1 citations

113 NITRIC OXIDE AND MULTIPLE ORGAN FAILURE

1995 • 1 citations

Deleted Work

1955 • 0 citations