Multiple Organ Failure Syndrome in the 1990s

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

ACUTE RESPIRATORY DISTRESS IN ADULTS

1967 • 4,096 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

An Expanded Definition of the Adult Respiratory Distress Syndrome

1988 • 2,636 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

1989 • 1,951 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients

1988 • 1,808 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Multiple-Organ Failure

1985 • 1,314 citations

Prognosis in Acute Organ-System Failure

1985 • 1,248 citations

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

1984 • 1,136 citations

Epidemiology of trauma deaths

1980 • 844 citations

Multiple Organ Failure

1999 • 820 citations

Adult Respiratory Distress Syndrome: Risk with Common Predispositions

1983 • 810 citations

[Multiple organ failure syndrome].

1988 • 795 citations

Multiple System Organ Failure

1980 • 751 citations

A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis

1991 • 741 citations

Clinical predictors of the adult respiratory distress syndrome

1982 • 684 citations

Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome

1983 • 654 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients

1987 • 559 citations

Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock

1992 • 555 citations

Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome.

1992 • 544 citations

Multiple Organ Failure in Polytrauma Patients

1983 • 492 citations

Multiple, Progressive, or Sequential Systems Failure

1975 • 478 citations

The Gut as a Portal of Entry for Bacteremia Role of Protein Malnutrition

1987 • 468 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Patterns Of Septic Shock In Man—a Detailed Study Of 56 Patients

1967 • 384 citations

Preoperative Optimization of Cardiovascular Hemodynamics Improves Outcome in Peripheral Vascular Surgery

1991 • 373 citations

A Controlled Trial in Intensive Care Units of Selective Decontamination of the Digestive Tract with Nonabsorbable Antibiotics

1992 • 367 citations

Hypermetabolism, organ failure, and metabolic support.

1987 • 362 citations

The Gut Origin Septic States in Blunt Multiple Trauma (ISS = 40) in the ICU

1987 • 352 citations

Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia

1988 • 338 citations

The Microbiology of Multiple Organ Failure

1988 • 330 citations

Septic Autocannibalism

1980 • 326 citations

Sequential System Failure after Rupture of Abdominal Aortic Aneurysms

1973 • 292 citations

Mathematic Coupling of Data

1981 • 290 citations

Physiological and metabolic correlations in human sepsis. Invited commentary.

1979 • 275 citations

Double-blind study of selective decontamination of the digestive tract in intensive care

1992 • 262 citations

Prevention of colonization and infection in critically ill patients

1988 • 253 citations

Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation.

1988 • 248 citations

Physiological and metabolic correlations in human sepsis

1980 • 244 citations

The Importance of Lipid Type in the Diet after Burn Injury

1986 • 239 citations

Anti-Endotoxin Monoclonal Antibodies

1992 • 235 citations

Splanchnic and total body oxygen consumption differences in septic and injured patients.

1987 • 229 citations

Oxygen Uptake/Supply Dependency: Effects of Short-term Dobutamine Infusion

1990 • 221 citations

Determinants of Organ Malfunction or Death in Patients With Intra-abdominal Sepsis

1983 • 216 citations

Remote organ failure: a valid sign of occult intra-abdominal infection.

1977 • 208 citations

Oxygen delivery and consumption in patients with hyperdynamic septic shock

1987 • 207 citations

Monoclonal antibody to TN F in severe septic shock

1990 • 203 citations

Immunosuppression and Intestinal Bacterial Overgrowth Synergistically Promote Bacterial Translocation

1988 • 184 citations

Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients

1983 • 183 citations

Oxygen Consumption Is Independent of Increases in Oxygen Delivery by Dobutamine in Septic Patients Who Have Normal or Increased Plasma Lactate

1993 • 174 citations

Inhibition of Cyclo-oxygenase Attenuates the Metabolic Response to Endotoxin in Humans

1988 • 171 citations

Dietary lipids, eicosanoids, and the immune system

1990 • 164 citations

Adult Respiratory Distress Syndrome

1992 • 161 citations

Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract

1992 • 157 citations

The systemic septic response

1980 • 154 citations

The Discovery of Nitric Oxide in the Vessel Wall

1993 • 150 citations

Enteral nutrition does not prevent multiple organ failure syndrome (MOFS) after sepsis.

1988 • 149 citations

Branched Chain Metabolic Support

1984 • 148 citations

APACHE II Score Does Not Predict Multiple Organ Failure or Mortality in Postoperative Surgical Patients

1990 • 148 citations

Posttraumatic Complications and Inflammatory Mediators

1986 • 147 citations

Selective Gut Decontamination Reduces Nosocomial Infections and Length of Stay but Not Mortality or Organ Failure in Surgical Intensive Care Unit Patients

1992 • 140 citations

Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance.

1991 • 138 citations

Multiple Systems Organ Failure: Muscle Fuel Deficit with Visceral Protein Malnutrition

1976 • 137 citations

Causes of Death after Blunt Trauma

1982 • 136 citations

Energy Metabolism and Proteolysis in Traumatized and Septic Man

1976 • 123 citations

Does drainage of intraabdominal pus reverse multiple organ failure?

1985 • 119 citations

Incidence of necrotizing pancreatitis and factors related to mortality

1987 • 113 citations

The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure.

1991 • 111 citations

Regulation of tissue oxygen extraction is disturbed in adult respiratory distress syndrome.

1985 • 103 citations

Oxygen consumption in sepsis and septic shock

1991 • 99 citations

Oxygen Delivery and Uptake by Peripheral Tissues: Physiology and Pathophysiology

1989 • 99 citations

Etiology of Multiple Organ Failure

1990 • 97 citations

The Effect of Stress Level, Amino Acid Formula, and Nitrogen Dose on Nitrogen Retention in Traumatic and Septic Stress

1987 • 97 citations

The Hypermetabolism

1989 • 95 citations

Correlations between Metabolic and Cardiopulmonary Measurements in Patients after Trauma, General Surgery, and Sepsis

1979 • 94 citations

The Natural History of Major Burns with Multiple Subsystem Failure

1983 • 90 citations

Nitrogen retention in critically ill patients is proportional to the branched chain amino acid load

1983 • 84 citations

Secondary Organ Dysfunction: From Clinical Perspectives to Molecular Mediators

1993 • 81 citations

Intensive Care Unit Survival of Patients with Systemic Illness

1989 • 81 citations

Lactate Levels as Predictors of the Relationship between Oxygen Delivery and Consumption in ARDS

1990 • 80 citations

Proline Metabolism in Sepsis, Cirrhosis and General Surgery The Peripheral Energy Deficit

1979 • 79 citations

Selective decontamination of the digestive tract in the intensive care unit

1992 • 75 citations

Mechanisms of Multiple Nonpulmonary Organ Failure in ARDS

1989 • 75 citations

Organ Failure and Multiple Organ System Failure in Pancreatitis

1991 • 73 citations

Multiple Systems Organ Failure

1985 • 72 citations

Risk Factors for Multiorgan Failure

1991 • 71 citations

The influence of sepsis and multisystem and organ failure on mortality in the surgical intensive care unit.

1984 • 67 citations

Clinical analysis of multiple organ failure in burned patients

1987 • 67 citations

Prolonged Surgical Intensive Care

1985 • 56 citations

Use of continuous noninvasive measurement of oxygen consumption in patients with adult respiratory distress syndrome following shock of various etiologies

1991 • 53 citations

Circulatory Disturbances in Multiple Systems Organ Failure

1989 • 52 citations

Independent Oxygen Uptake and Oxygen Delivery in Septic and Postoperative Patients

1991 • 48 citations

The Effects of Intralipid and Heparin on Human Monocyte and Lymphocyte Function

1984 • 40 citations

The Effect on Survival of Critically Ill and Injured Patients of an ICU Teaching Service Organized About a Computer-based Physiologic CARE System

1980 • 39 citations

Physiology and Metabolism in Isolated Viral Septicemia

1987 • 36 citations

Cellular Oxygen Utilization During Multiple Organ Failure

1989 • 32 citations

Nutritional pharmacology

1990 • 28 citations

Postoperative Acute Gastrointestinal Tract Hemorrhage and Multiple-Organ Failure

1988 • 27 citations

The Systemic Septic Response

1990 • 25 citations

Modification of Oxygen Extraction Ratio by Change in Oxygen Transport in Septic Shock

1992 • 25 citations

Microthrombosis during endotoxemia: Potential role of hepatic versus alveolar macrophages

1984 • 25 citations

Scoring systems and predictors of ARDS and MOF.

1987 • 24 citations

Regulation of Tissue Oxygen Extraction Is Disturbed in Adult Respiratory Distress Syndrome

1986 • 24 citations

The role of the complement system in the pathogenesis of multiple organ failure in shock.

1989 • 22 citations

Antiendotoxin Monoclonal Antibodies

1994 • 19 citations

Pulmonary effects of intralipid: The role of intralipid as a prostaglandin precursor

1981 • 15 citations

Metabolic abnormalities of mitochondrial redox potential in postburn multiple system organ failure

1992 • 14 citations

Multiple System Organ Failure and the Sepsis Syndrome

1991 • 12 citations

Hepatic dysfunction in multiple systems organ failure as a manifestation of altered cell-cell interaction.

1989 • 7 citations

Cost‐effective use of the surgical intensive care unit

1987 • 2 citations