Laboratory models of sepsis and septic shock

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Profound but Reversible Myocardial Depression in Patients with Septic Shock

1984 • 1,518 citations

Sepsis and septic shock—A review of laboratory models and a proposal

1980 • 1,441 citations

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Causes of Mortality in Patients With the Adult Respiratory Distress Syndrome

1986 • 798 citations

The Effects of High-Dose Corticosteroids in Patients with Septic Shock

1984 • 761 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

Clinical predictors of the adult respiratory distress syndrome

1982 • 684 citations

Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.

1983 • 507 citations

Serial cardiovascular variables in survivors and nonsurvivors of human septic shock

1987 • 502 citations

The coronary circulation in human septic shock.

1986 • 466 citations

Increased Sheep Lung Vascular Permeability Caused by Pseudomonas Bacteremia

1974 • 434 citations

Preparation of chronic lung lymph fistulas in sheep

1975 • 401 citations

Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

1987 • 370 citations

The Microbiology of Multiple Organ Failure

1988 • 330 citations

ENDOTOXAEMIA: AN EARLY PREDICTOR OF SEPTICAEMIA IN FEBRILE PATIENTS

1988 • 317 citations

Effect of Injury and Infection on Visceral Metabolism and Circulation

1980 • 290 citations

van Deventer H

1968 • 280 citations

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.

1986 • 267 citations

Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

1986 • 260 citations

Hemodynamic determinants of mortality in human septic shock

1986 • 243 citations

Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice

1984 • 237 citations

Septic shock. Hemodynamics and pathogenesis.

1983 • 229 citations

Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.

1989 • 217 citations

Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock

1974 • 180 citations

Limitations of the Usefulness of the Limulus Assay for Endotoxin

1973 • 180 citations

Inhibition of Cyclo-oxygenase Attenuates the Metabolic Response to Endotoxin in Humans

1988 • 171 citations

Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis

1984 • 171 citations

Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver.

1989 • 169 citations

The systemic septic response

1980 • 154 citations

Lack of Clinical Usefulness of the Limulus Test in the Diagnosis of Endotoxemia

1975 • 152 citations

Effect of vasopressors on organ blood flow during endotoxin shock in pigs

1987 • 143 citations

Effect of lipopolysaccharide on intestinal intramucosal hydrogen ion concentration in pigs

1989 • 135 citations

Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis.

1980 • 133 citations

Distribution of respiratory muscle and organ blood flow during endotoxic shock in dogs

1985 • 114 citations

The Surgical Intensive Care Unit: Current Concepts in Infection

1980 • 107 citations

Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey

1982 • 101 citations

The role of endotoxin during typhoid fever and tularemia in man

1969 • 87 citations

Evaluation of cardiac output, total peripheral vascular resistance, and plasma concentrations of vasopressin in the conscious, unrestrained rat during endotoxemia.

1985 • 85 citations

Protection of mice against lethal endotoxemia by a lipid A precursor

1986 • 85 citations

Inhibition of Prostaglandin Synthesis Restores Normal Hemodynamics in Canine Hyperdynamic Sepsis

1984 • 84 citations

Cardiovascular performance with E. coli challenges in a canine model of human sepsis

1988 • 83 citations

A New Model for Studying Nutrition in Peritonitis

1989 • 79 citations

Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver

1986 • 78 citations

Sequential cardiorespiratory patterns in septic shock

1983 • 75 citations

Meehanisms for the High Circulatory Requirements in Sepsis and Septic Shock

1969 • 74 citations

Continuous infusion of endotoxin from an osmotic pump in the conscious, unrestrained rat: a unique model of chronic endotoxemia.

1984 • 72 citations

Skeletal Microcirculatory Responses to Hyperdynamic Escherichia coli Sepsis in Unanesthetized Rats

1987 • 67 citations

Survival of primates in lethal septic shock following delayed treatment with steroid.

1981 • 61 citations

Regional blood flow during continuous low-dose endotoxin infusion.

1986 • 59 citations

Glucose and lactate metabolism in experimental septic shock

1978 • 58 citations

Effectiveness of Steroid/Antibiotic Treatment in Primates Administered LD100 Escherichia coli

1981 • 57 citations

Bacteremia: host-specific lung clearance and pulmonary failure.

1981 • 55 citations

Comparison of live bacteria infusions in a porcine model of acute respiratory failure

1983 • 55 citations

Systemic and mesenteric O2 metabolism in endotoxic pigs: effect of ibuprofen and meclofenamate

1989 • 53 citations

Effects of endotoxin on distribution of cardiac output in unanesthetized rabbits

1970 • 51 citations

Mesenteric vascular responses to endotoxin in the monkey and dog

1970 • 50 citations

Cardiopulmonary responses to continuous administration of endotoxin

1988 • 48 citations

Sustained hypermetabolic sepsis in rats: Characterization of the model

1983 • 48 citations

A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans.

1984 • 47 citations

Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis

1988 • 46 citations

Increased lymphatic elimination of interstitial hyaluronan during E. coli sepsis in sheep

1989 • 43 citations

The Role of C5 in Septic Lung Injury

1985 • 41 citations

Septic shock. Hemodynamics and pathogenesis

1983 • 40 citations

Removal of abdominal sources of caudal mediastinal node lymph in anesthetized sheep

1983 • 40 citations

Comparison of canine responses to Escherichia coli organisms and endotoxin.

1968 • 39 citations

Bacteremia

1981 • 39 citations

Systemic and regional hemodynamic changes after intraperitoneal endotoxin in rabbits: development of a new model of the clinical syndrome of hyperdynamic sepsis.

1987 • 38 citations

THE INCREASE OF CIRCULATORY REQUIREMENTS IN THE PRESENCE OF INFLAMMATION.

1964 • 38 citations

Peripheral lymph flow in sheep with bacterial peritonitis: evidence for increased peripheral microvascular permeability accompanying systemic sepsis.

1985 • 38 citations

Physiology and Metabolism in Isolated Viral Septicemia

1987 • 36 citations

Hemodynamic effects of continuous norepinephrine infusion in dogs with and without hyperkinetic endotoxic shock

1987 • 35 citations

Adult respiratory distress syndrome. A live E coli septic primate model.

1987 • 34 citations

Effects of endotoxin on regional blood flow in the unanesthetized guinea pig

1978 • 34 citations

Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis.

1985 • 32 citations

Induction of Hypermetabolism in Guinea Pigs by Endotoxin Infused Through the Portal Vein

1988 • 32 citations

Canine left ventricular performance during LD50 endotoxemia

1983 • 31 citations

Pulmonary clearance of blood-borne bacteria.

1981 • 31 citations

The pulmonary and systemic response to recurrent endotoxemia in the adult sheep.

1986 • 30 citations

A comparison of Escherichia coli endotoxin single bolus injection with low-dose endotoxin infusion on pulmonary and systemic vascular changes.

1987 • 29 citations

Naloxone alters organ perfusion during endotoxin shock in conscious rats

1988 • 29 citations

Left ventricular function during chronic endotoxemia in swine

1988 • 28 citations

Association between renal and sympathetic responses to nonhypotensive systemic sepsis

1988 • 27 citations

Effects of continuous intravenous infusion of Escherichia coli endotoxin into swine.

1982 • 27 citations

Effects of ibuprofen on a pig Pseudomonas ARDS model

1986 • 26 citations

Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits.

1988 • 26 citations

Renal hemodynamics and prostaglandin E2 excretion in a nonhuman primate model of septic shock

1990 • 25 citations

Myocardial dysfunction in a nonlethal, nonshock model of chronic endotoxemia.

1985 • 25 citations

Successful treatment of adult respiratory distress syndrome by histamine and prostaglandin blockade in a porcine Pseudomonas model.

1987 • 24 citations

Endotoxin sensitivity of inbred mouse strains

1973 • 24 citations

A model of ovine endotoxemia characterized by an increased cardiac output.

1985 • 24 citations

Prostaglandins maintain renal microvascular blood flow during hyperdynamic bacteremia.

1988 • 23 citations

Complement Depletion with Naje haje Cobra Venom Factor Limits Prostaglandin Release and Improves Visceral Perfusion in Porcine Endotoxic Shock

1989 • 22 citations

Effects of slow intravenous endotoxin infusion on hemodynamics and survival in dogs.

1967 • 21 citations

Case 10-1975

1975 • 20 citations

Cardiopulmonary response of the rat to gram-negative bacteremia

1984 • 20 citations

Salmonellosis in Mice Infected with Mycobacterium tuberculosis BCG I. Role of Endotoxin in Infection

1968 • 20 citations

Hemodynamic responses to sepsis: Hypodynamic versus hyperdynamic states

1981 • 18 citations

Comparison of effects of dextran-70 and Ringerʼs acetate on pulmonary function, hemodynamics, and survival in experimental septic shock

1988 • 18 citations

Chronic hyperdynamic sepsis in the rat: I. Characterization of the animal model.

1988 • 15 citations

Ibuprofen Plus Prostaglandin E1 in a Septic Porcine Model of Adult Respiratory Distress Syndrome

1989 • 15 citations

Route of endotoxin delivery; effects on canine mesenteric hemodynamics

1972 • 14 citations

Hypoglycemic depression of RES function

1976 • 13 citations

Evaluation of Naloxone Therapy for Escherichia coli Sepsis in the Baboon

1988 • 13 citations

Cardiorespiratory patterns in viral septicemia

1987 • 12 citations

Hyper and hypodynamic models of sepsis in guinea pigs

1989 • 10 citations

Indomethacin Improvement of Septic Acute Respiratory Failure in a Porcine Model

1983 • 10 citations

The Association of Escherichia coli Virulence and Pulmonary Microvascular Damage

1989 • 2 citations

Effect of endotoxin on diaphragm lymph contamination in unanesthetized sheep

1987 • 2 citations

Deleted Work

1955 • 0 citations