Immunity by ubiquitylation: a reversible process of modification

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

2004 • 1,759 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

T Cell Anergy

2003 • 1,418 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

2000 • 1,374 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

2004 • 1,063 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

2003 • 983 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

2003 • 932 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

NF-κB signaling pathways in mammalian and insect innate immunity

2001 • 892 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

2004 • 821 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA

2003 • 627 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

2003 • 524 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

2002 • 501 citations

UBP43 (USP18) Specifically Removes ISG15 from Conjugated Proteins

2002 • 488 citations

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

2001 • 487 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

1987 • 430 citations

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

1990 • 417 citations

Control of mRNA Decay by Heat Shock-Ubiquitin-Proteasome Pathway

1999 • 395 citations

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

2004 • 386 citations

Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression

2000 • 383 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase

2004 • 367 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

The Ubiquitin Ligase SCF ^Fbw7 Antagonizes Apoptotic JNK Signaling

2004 • 345 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

Protein ISGylation modulates the JAK-STAT signaling pathway

2003 • 313 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

2001 • 304 citations

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

2001 • 304 citations

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein

2004 • 295 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

GRAIL

2003 • 280 citations

Ubiquitin Ligases and the Immune Response

2004 • 277 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

2000 • 273 citations

Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection

2004 • 270 citations

Otubains: a new family of cysteine proteases in the ubiquitin pathway

2003 • 258 citations

The Kinase Activity of Rip1 Is Not Required for Tumor Necrosis Factor-α-induced IκB Kinase or p38 MAP Kinase Activation or for the Ubiquitination of Rip1 by Traf2

2004 • 251 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

High-throughput Immunoblotting

2003 • 245 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim

2003 • 239 citations

Back to Central Tolerance

2004 • 202 citations

ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not Essential for STAT1 Signaling and Responses against Vesicular Stomatitis and Lymphocytic Choriomeningitis Virus

2005 • 197 citations

The Autoimmune Regulator (AIRE) Is a DNA-binding Protein

2001 • 172 citations

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation

2000 • 168 citations

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

2003 • 163 citations

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

2001 • 152 citations

Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence.

1986 • 151 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

PHD domains and E3 ubiquitin ligases: viruses make the connection

2002 • 145 citations

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB

2002 • 137 citations

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

1994 • 133 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

1995 • 125 citations

Itch E3 Ligase-Mediated Regulation of TGF-β Signaling by Modulating Smad2 Phosphorylation

2004 • 116 citations

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

2004 • 113 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas

1997 • 62 citations

The ISG15 Isopeptidase UBP43 Is Regulated by Proteolysis via the SCFSkp2 Ubiquitin Ligase

2004 • 51 citations

Signals involved in thymocyte positive and negative selection

1999 • 39 citations

Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase

2003 • 37 citations

Perspectives on PKC? in T cell activation

2004 • 34 citations