Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

UBP43 (USP18) Specifically Removes ISG15 from Conjugated Proteins

2002 • 488 citations

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

2001 • 487 citations

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

1987 • 430 citations

The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.

1992 • 420 citations

Protein ISGylation modulates the JAK-STAT signaling pathway

2003 • 313 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cells

1979 • 297 citations

High-throughput Immunoblotting

2003 • 245 citations

Genomic and Biological Variation among Commonly Used Lymphocytic Choriomeningitis Virus Strains

1983 • 241 citations

Initial and innate responses to viral infections — pattern setting in immunity or disease

1999 • 241 citations

Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

2001 • 177 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

Dysregulation of protein modification by ISG15 results in brain cell injury

2002 • 156 citations

ISG15: the immunological kin of ubiquitin

2004 • 137 citations

Serpin 2a Is Induced in Activated Macrophages and Conjugates to a Ubiquitin Homolog

2002 • 90 citations

CTL Escape Viral Variants

1995 • 83 citations

Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions

1989 • 80 citations

Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein

2003 • 78 citations

ISG15, not just another ubiquitin-like protein

2003 • 66 citations

Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice

1977 • 66 citations

T Cells in the Central Nervous System: The Delicate Balance between Viral Clearance and Disease

2002 • 54 citations

Lethal Role of Interferon in Lymphocytic Choriomeningitis Virus-induced Encephalitis

1983 • 33 citations

Alteration of cellular resistance to Sindbis virus in mixed cultures of human cells attributable to interferon

1962 • 32 citations

Heterogeneity of the sensitivity of vesicular stomatitis virus to interferons

1977 • 29 citations

Lack of Correlation between Serum Titres of Interferon ,beta, Natural Killer Cell Activity and Clinical Susceptibility in Mice Infected with Two Isolates of Lymphocytic Choriomeningitis Virus

1987 • 17 citations

Class I MHC Molecule-Mediated Inhibition of Sindbis Virus Replication

1999 • 10 citations

Cell‐Mediated Immunity in Virus Infections of the Central Nervous System

1988 • 3 citations