A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

A stable genomic source of P element transposase in Drosophila melanogaster.

1988 • 1,359 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster

1976 • 395 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily

1990 • 361 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye

1990 • 313 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

Function of torso in determining the terminal anlagen of the Drosophila embryo

1988 • 228 citations

Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster.

1990 • 227 citations

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 • 219 citations

Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

1989 • 219 citations

The genetics of Drosophila

1988 • 218 citations

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1993 • 217 citations

Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

1989 • 213 citations

Cell-cell interaction in the drosophila retina: The bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

1988 • 209 citations

Sevenless : A Cell-Specific Homeotic Mutation of the Drosophila Eye

1986 • 197 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

1989 • 163 citations

Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg

1992 • 154 citations

The SRF and MCM1 transcription factors

1992 • 123 citations

bicoid and the terminal system activate tailless expression in the early Drosophila embryo

1992 • 121 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

GENETIC ANALYSIS OF THE CENTROMERIC HETEROCHROMATIN OF CHROMOSOME 2 OF DROSOPHILA MELANOGASTER: DEFICIENCY MAPPING OF EMS-INDUCED LETHAL COMPLEMENTATION GROUPS

1976 • 114 citations

Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.

1993 • 110 citations

Behaviour of cells mutant for an EGFreceptorhomologue ofDrosophilain genetic mosaics

1990 • 110 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

The torso receptor protein-tyrosine kinase signaling pathway: An endless story

1993 • 101 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.

1989 • 99 citations

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.

1992 • 80 citations

Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. II. Mutations on the second chromosome.

1989 • 80 citations

Cytogenetic Analysis of the Third Chromosome Heterochromatin of Drosophila melanogaster

2002 • 63 citations

Ultrastructure of the retina ofDrosophila melanogaster: The mutantora(outer rhabdomeres absent) and its inhibition of degeneration inrdgB(retinal degeneration-B)

1987 • 55 citations

Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. I. Mutations on the third chromosome.

1989 • 54 citations

Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster.

1991 • 52 citations

Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless.

1988 • 26 citations

Ultrastructure of the retina of Drosophila melanogaster. the mutant ora (outer rhabdomeres absent) and its inhibition of degeneration in rdgB (retinal degeneration-B)

1987 • 22 citations

Role of arafproto-oncogene duringCaenorhabditis elegansvulval development

1993 • 14 citations