Therapies directed at vascular endothelial growth factor

The Hallmarks of Cancer

2000 • 27,569 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1999 • 2,034 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

2001 • 1,640 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Anti-cancer Drug Design

2018 • 1,309 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

1994 • 1,269 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Neuropilin Is a Semaphorin III Receptor

1997 • 1,166 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1

2002 • 1,066 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Tumor angiogenesis: past, present and the near future

2000 • 973 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

Phase I Safety and Pharmacokinetic Study of Recombinant Human Anti-Vascular Endothelial Growth Factor in Patients With Advanced Cancer

2001 • 923 citations

Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

1999 • 866 citations

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

2000 • 848 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

2001 • 759 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Vascular endothelial growth factor enhances atherosclerotic plaque progression

2001 • 711 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

2000 • 676 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

1999 • 660 citations

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

2001 • 652 citations

Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I Studies

2003 • 651 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

1993 • 645 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

1998 • 552 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue.

1994 • 524 citations

How Tumors Become Angiogenic

1996 • 514 citations

Anti-VEGF Antibody Treatment of Glioblastoma Prolongs Survival But Results in Increased Vascular Cooption

2000 • 512 citations

Angiogenesis: Implications for rheumatoid arthritis

1998 • 512 citations

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

2000 • 501 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

1999 • 491 citations

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

1998 • 474 citations

Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma

1995 • 469 citations

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1993 • 467 citations

Vascular Endothelial Growth Factor, a Possible Paracrine Growth Factor in Human Acute Myeloid Leukemia

1997 • 465 citations

Antibodies against Vascular Endothelial Growth Factor Improve Early Renal Dysfunction in Experimental Diabetes

2001 • 449 citations

Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.

2001 • 440 citations

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

2000 • 435 citations

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

1995 • 430 citations

VEGF is major stimulator in model of choroidal neovascularization.

2000 • 430 citations

Effect of p53 Status on Tumor Response to Antiangiogenic Therapy

2002 • 427 citations

Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.

2001 • 401 citations

Role of Vascular Endothelial Growth Factor in Ovarian Cancer

1998 • 396 citations

Concurrent Induction of Lymphangiogenesis, Angiogenesis, and Macrophage Recruitment by Vascular Endothelial Growth Factor-C in Melanoma

2001 • 390 citations

Angiogenesis and Remodeling of Airway Vasculature in Chronic Inflammation

2001 • 373 citations

Phase Ib Trial of Intravenous Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor in Combination With Chemotherapy in Patients With Advanced Cancer: Pharmacologic and Long-Term Safety Data

2001 • 369 citations

Neuropilin-1 Is a Placenta Growth Factor-2 Receptor

1998 • 344 citations

Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma

2001 • 344 citations

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.

1999 • 341 citations

Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization

2000 • 340 citations

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1996 • 336 citations

Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.

1995 • 329 citations

Vascular Endothelial Growth Factors VEGF-B and VEGF-C Are Expressed in Human Tumors

1998 • 328 citations

Comparison of microscopic vascularity in benign and malignant prostate tissue

1993 • 327 citations

Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

1993 • 314 citations

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

2002 • 308 citations

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

1999 • 304 citations

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

2001 • 300 citations

Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121

2001 • 298 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) Expression and Angiogenesis in Cervical Neoplasia

1995 • 285 citations

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer

2001 • 276 citations

Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications

2001 • 265 citations

Vascular permeability factor gene expression in normal and neoplastic human ovaries.

1994 • 259 citations

Requirements for Binding and Signaling of the Kinase Domain Receptor for Vascular Endothelial Growth Factor

1998 • 256 citations

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface

1998 • 255 citations

Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors

2002 • 253 citations

Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1)

2001 • 252 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent.

2000 • 237 citations

Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours

1994 • 234 citations

Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

1999 • 233 citations

Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer

2000 • 232 citations

Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.

1997 • 225 citations

Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis

2000 • 218 citations

Release and Complex Formation of Soluble VEGFR-1 from Endothelial Cells and Biological Fluids

2000 • 217 citations

Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells.

2001 • 214 citations

New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis

2000 • 214 citations

Expression of vascular endothelial growth factor receptors in human prostate cancer

1999 • 202 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas.

1996 • 200 citations

Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells

1996 • 200 citations

Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody

1999 • 198 citations

Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1

1997 • 198 citations

Vascular Progenitors From Biology to Treatment

2002 • 197 citations

Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin.

2000 • 195 citations

ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy.

2000 • 195 citations

Human neutrophils secrete vascular endothelial growth factor

1997 • 193 citations

Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.

1994 • 190 citations

Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect

2001 • 190 citations

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

2001 • 185 citations

Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases.

1996 • 183 citations

Current biology of VEGF-B and VEGF-C

1999 • 183 citations

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration

2000 • 181 citations

Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma.

1992 • 173 citations

Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis.

1995 • 172 citations

Human Melanoma Cells Secrete and Respond to Placenta Growth Factor and Vascular Endothelial Growth Factor

2000 • 171 citations

Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth

2001 • 161 citations

Treatment with Soluble VEGF Receptor Reduces Disease Severity in Murine Collagen-Induced Arthritis

2000 • 160 citations

NEUTRALIZING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR ANTIBODY INHIBITS FURTHER GROWTH OF ESTABLISHED PROSTATE CANCER AND METASTASES IN A PRE-CLINICAL MODEL

1999 • 160 citations

Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors.

2000 • 156 citations

VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis

2000 • 155 citations

Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.

2000 • 153 citations

Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy

1999 • 144 citations

Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia

2001 • 139 citations

Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas

1996 • 132 citations

Human airway smooth muscle cells secrete vascular endothelial growth factor: up‐regulation by bradykinin via a protein kinase C and prostanoid‐dependent mechanism

2001 • 130 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma

1996 • 126 citations

The significance of atypical vessels and neovascularization in cervical neoplasia

1981 • 123 citations

Prognostic significance of the microvascular count in colorectal cancer.

1996 • 113 citations

Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases

2000 • 109 citations

Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma.

1996 • 108 citations

Vascular Endothelial Growth Factor-Mediated Autocrine Stimulation of Prostate Tumor Cells Coincides with Progression to a Malignant Phenotype

2001 • 108 citations

Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas.

1999 • 106 citations

Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.

2001 • 105 citations

Characterization of indolinones which preferentially inhibit VEGF‐C‐ and VEGF‐D‐induced activation of VEGFR‐3 rather than VEGFR‐2

2001 • 104 citations

Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors.

1999 • 103 citations

Angiozyme: A Novel angiogenesis inhibitor

2001 • 101 citations

Vascular Endothelial Growth Factor Receptors in Human Mesangium in Vitro and in Glomerular Disease

2000 • 99 citations

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

2001 • 98 citations

Role of vascular endothelial growth factor (VEGF) and placenta‐derived growth factor (PlGF) in regulating human haemopoietic cell growth

1998 • 93 citations

Ischemia-Driven Angiogenesis

1997 • 91 citations

Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease

2000 • 86 citations

Expression and localization of placenta growth factor and PlGF receptors in human meningiomas

1999 • 85 citations

Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA

1999 • 78 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor Flk-1 in Benign, Premalignant, and Malignant Prostate Tissue

2001 • 77 citations

Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC

2000 • 74 citations

Monoclonal antibody strategies to block angiogenesis

2001 • 70 citations

Identification of the Residues in the Extracellular Region of KDR Important for Interaction with Vascular Endothelial Growth Factor and Neutralizing Anti-KDR Antibodies

2000 • 67 citations

von Hippel-Lindau Syndrome: Target for Anti-Vascular Endothelial Growth Factor (VEGF) Receptor Therapy

2000 • 64 citations

Wide Spectrum of Antitumor Activity of a Neutralizing Monoclonal Antibody to Human Vascular Endothelial Growth Factor

1999 • 63 citations

Co-Expression of Vascular Endothelial Growth Factor and Its Receptor <i>flt-1</i> in Malignant Pleural Mesothelioma

2000 • 52 citations

Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers.

2000 • 51 citations

Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody

1999 • 49 citations

Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: development and application of two new immunoassays

2001 • 45 citations

Pharmacokinetics of an Antiangiogenic Ribozyme (ANGIOZYME™) in the Mouse

1999 • 45 citations

Acute Toxicology and Pharmacokinetic Assessment of a Ribozyme (ANGIOZYME™) Targeting Vascular Endothelial Growth Factor Receptor mRNA in the Cynomolgus Monkey

2000 • 30 citations

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR AS A SURVEILLANCE MARKER FOR CELLULAR REJECTION IN PEDIATRIC CARDIAC TRANSPLANTATION

2002 • 30 citations

Anti-angiogenic therapy of proliferative diabetic retinopathy

2001 • 22 citations

Biotransformation of the anti-angiogenic compound SU5416.

2000 • 21 citations

Anti-VEGF Antibody HuMV833: an EORTC Biological Treatment Development Group Phase I Toxicity, Pharmacokinetic and Pharmacodynamic Study.

2001 • 19 citations

Chemical Approaches to the Study of Protein Tyrosine Kinases and Their Implications for Mechanism and Inhibitor Design

1999 • 19 citations

Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR

2003 • 18 citations

Cinnamamide analogs as inhibitors of protein tyrosine kinases.

1993 • 15 citations

Deleted Work

1955 • 0 citations