Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Kinetics of Response in Lymphoid Tissues to Antiretroviral Therapy of HIV-1 Infection

1997 • 631 citations

Validation of the general purpose QUANTA ®3.2/CHARMm® force field

1992 • 557 citations

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

1998 • 477 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1997 • 387 citations

Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

1993 • 367 citations

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

1996 • 319 citations

Human Vascular Permeability Factor

1989 • 282 citations

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1997 • 274 citations

Vegetal Messenger RNA Localization Directed by a 340-nt RNA Sequence Element in Xenopus Oocytes

1992 • 268 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

1995 • 259 citations

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

1997 • 201 citations

High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as Guides for Inhibitor Design

1996 • 197 citations

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

1999 • 196 citations

Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer

1996 • 163 citations

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

1997 • 150 citations

4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

1996 • 148 citations

Modelling study of protein kinase inhibitors: Binding mode of staurosporine and origin of the selectivity of CGP 52411

1995 • 95 citations

Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors

1998 • 84 citations

Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.

1993 • 84 citations

Receptor tyrosine kinases as targets for inhibition of angiogenesis

1997 • 78 citations

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

1977 • 75 citations

Growth factors and tyrosine protein kinases in normal and malignant melanocytes

1991 • 60 citations

A convective model for the zonal jets in the atmospheres of Jupiter and Saturn

1994 • 47 citations

Structures of bis(2-methoxyethylcyclopentadienyl) complexes of lanthanide chlorides

1993 • 32 citations

Synthesis and biological activity of some new furan quaternary salts

1977 • 11 citations

Furan and Tetrahydrofuran Derivatives. III. The Synthesis of Certain 3,4-Diaminofuran Derivatives¹

1945 • 5 citations