Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.

Mechanisms of angiogenesis

1997 • 5,696 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

1991 • 626 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

1997 • 527 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Expression of Angiogenesis-Related Genes and Progression of Human Ovarian Carcinomas in Nude Mice

1998 • 377 citations

Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation.

1995 • 280 citations

Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

1996 • 250 citations

Malignant Pleural Effusions

1985 • 238 citations

Regulation of distinct steps of angiogenesis by different angiogenic molecules.

1998 • 208 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Prognostic value of pleural effusion in patients with non-small cell lung cancer.

1997 • 154 citations

Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.

1999 • 124 citations

Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors.

1998 • 102 citations

Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody.

1998 • 86 citations

Vascular endothelial growth factor in malignant pleural effusion associated with lung cancer

1999 • 84 citations

An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells

1998 • 77 citations

Pleural effusion as a significant prognostic factor in non-small cell lung cancer.

1998 • 60 citations

Management of malignant pleural effusions.

1995 • 52 citations

Model of malignant pleural effusion of human lung adenocarcinoma in SCID mice.

1997 • 37 citations

Management of the malignant pleural effusion.

1994 • 19 citations

Management of malignant pleural effusion

1998 • 11 citations