Back to search

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

Data up to Jan 2025

Published2001
Citations98
References35

Total Citations Per Year

Abstract

References (35)

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Establishment and identification of small cell lung cancer cell lines having classic and variant features

1986 • 896 citations

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

1995 • 895 citations

Stem Cell Factor and Hematopoiesis

1997 • 850 citations

The biology of stem cell factor and its receptor C-kit

1999 • 564 citations

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

2000 • 501 citations

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

1998 • 474 citations

Activating c-kit Gene Mutations in Human Germ Cell Tumors

1999 • 414 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor.

1996 • 275 citations

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

2000 • 271 citations

Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer.

1991 • 258 citations

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

1999 • 253 citations

Preferential expression of c-kit protooncogene transcripts in small cell lung cancer

1992 • 182 citations

Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumors.

1991 • 180 citations

Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts

1993 • 164 citations

Coexpression of the c-kit receptor and the stem cell factor in gynecological tumors.

1994 • 153 citations

Coexpression of the c-kit and stem cell factor genes in breast carcinomas.

1995 • 151 citations

Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group

1994 • 135 citations

Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors

1992 • 133 citations

Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group

1994 • 121 citations

ATP site-directed competitive and irreversible inhibitors of protein kinases

2000 • 117 citations

Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction

1994 • 116 citations

c-kit Is Expressed in Soft Tissue Sarcoma of Neuroectodermic Origin and Its Ligand Prevents Apoptosis of Neoplastic Cells

1998 • 105 citations

c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines.

1993 • 64 citations

Expression of c-<i>kit</i> and <i>kit</i> Ligand in Human Colon Carcinoma Cells

1993 • 52 citations

Indolinone Derivatives Inhibit Constitutively Activated KIT Mutants and Kill Neoplastic Mast Cells

2000 • 46 citations

Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.

1997 • 33 citations

Protein kinase inhibitors: structural determinants for target specificity.

1998 • 32 citations

Cited By (0)

Loading...
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung… (2001) – PubMed | Metascience Observatory Explorer