Characterization of indolinones which preferentially inhibit VEGF‐C‐ and VEGF‐D‐induced activation of VEGFR‐3 rather than VEGFR‐2

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

2001 • 1,707 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1995 • 1,421 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

2001 • 759 citations

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

1996 • 684 citations

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

2001 • 652 citations

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

2000 • 625 citations

Vascular endothelial growth factor C induces angiogenesis in vivo

1998 • 558 citations

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

1997 • 501 citations

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

2000 • 501 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Congenital Hereditary Lymphedema Caused by a Mutation That Inactivates VEGFR3 Tyrosine Kinase

2000 • 415 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Lymphangiogenesis and tumor metastasis: myth or reality?

2001 • 364 citations

Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia

1998 • 353 citations

Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers

1999 • 330 citations

Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.

1996 • 315 citations

c- fos -induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro

1999 • 271 citations

Hereditary lymphedema: evidence for linkage and genetic heterogeneity

1998 • 271 citations

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

1999 • 253 citations

A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities

1998 • 252 citations

Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity

1998 • 195 citations

Signaling angiogenesis and lymphangiogenesis

1998 • 182 citations

血小板由来増殖因子/血管内皮増殖因子ファミリーと相関するc‐fos誘導性遺伝子の同定

1996 • 138 citations

Vascular Endothelial Growth Factor Receptor-3

1999 • 109 citations

Variant Exons v6 and v7 Together Expand the Repertoire of Glycosaminoglycans Bound by CD44

1997 • 95 citations

Proliferation of lymphatics in inflammation

1937 • 88 citations

Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein

1998 • 87 citations

Xenopus A-myb is expressed during early spermatogenesis.

1993 • 72 citations

Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution

2000 • 65 citations

The histology of experimental pleural injury with tetracycline, empyema, and carrageenan

1989 • 61 citations

Characterization of murine Flt4 ligand/VEGF-C

1997 • 45 citations

Stage T1A carcinoma of prostate

1994 • 31 citations

Lymphatic Regeneration Following Microvascular Limb Replantation: A Qualitative and Quantitative Animal Study

1997 • 28 citations

Limbal lymphangiogenesis after corneal injury: an autoradiographic study

1989 • 26 citations

Functional characterization of HLA‐DRA11 0101/ DRB1* 0401 molecules expressed in Drosophila melanogaster cells

1998 • 18 citations

The Lymphatic System

1974 • 14 citations