Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

Angiogenic Factors

1987 • 3,702 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Angiogenesis.

1992 • 2,581 citations

Head and Neck Cancer

1993 • 2,263 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Cancer statistics, 1992

1992 • 540 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.

1988 • 538 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

1991 • 259 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx.

1992 • 204 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

p53 and c-erbB-2 Protein Expression in Breast Carcinomas: An Immunohistochemical Study Including Correlations with Receptor Status, Proliferation Markers, and Clinical Stage in Human Breast Cancer

1992 • 126 citations

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

1993 • 120 citations

Immunohistochemical analysis of monoclonal antibodies to renal antigens. Application in the diagnosis of renal cell carcinoma.

1986 • 105 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

A monoclonal antibody reacting with endothelial cells of budding vessels in tumors and inflammatory tissues, and non‐reactive with normal adult tissues

1986 • 68 citations

The american journal of pathology-are we there?

1993 • 37 citations

Synchronous Radiotherapy and Chemotherapy with Cisplatin in the Management of Locally Advanced or Recurrent Head and Neck Cancer

1992 • 14 citations